veratramine/veratrum

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Pharmacokinetics and metabolism study of veratramine in mice after oral administration using LC-MS/MS.

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Ingia / Ingia

A simple and sensitive high-performance liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry (Q-trap-MS) method was developed and validated for the determination of veratramine, the major bioactive and neurotoxic component in Veratrum nigrum L. Veratramine

Identification and characterization of in vitro and in vivo metabolites of steroidal alkaloid veratramine.

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Ingia / Ingia

Veratramine, a steroidal alkaloid originating from Veratrum nigrum L., has demonstrated distinct anti-tumor and anti-hypertension effects, however, its metabolism has rarely been explored. The objective of the current study was to provide a comprehensive investigation of its metabolic pathways. The

Gender-Dependent Pharmacokinetics of Veratramine in Rats: In Vivo and In Vitro Evidence.

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Ingia / Ingia

Veratramine, a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. Our previous study indicated that veratramine had severe toxicity toward male rats. In order to elucidate the underling mechanism, in vivo pharmacokinetic experiments and in vitro

Metabolism Study of Veratramine Associated with Neurotoxicity by Using HPLC-MSn.

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Ingia / Ingia

Veratramine (VAM) is the major lipid-soluble alkaloid existing in Veratrum nigrum L. that has been demonstrated to exert neurotoxic effects. To better understand the potential mechanism of neurotoxicity of VAM, VAM-induced DNA damage was measured in the cerebellum and cerebral cortex of mice after a

Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats.

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Ingia / Ingia

Total alkaloids (VTA) and veratramine of Veratrum nigrum L. were tested for hypotensive effect using spontaneously hypertensive rats (SHR). Acute toxicities were also evaluated. There was a dose-dependent reduction in blood pressure and heart rate after a single ingestion (1.0 to 4.0 mg/kg,

Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense.

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Ingia / Ingia

Veratrum taliense is traditionally used TCMs in Yunnan province of China for pain and inflammation. Previous research and clinical applications have shown that V. taliense had significant analgesic activity. Jevine-type alkaloids were shown to be one of the anti-inflammatory and

Time course and inhibition of stavaroside K, veratramine and cevine-induced hemolysis by other pregnane glycosides and Veratrum alkaloids.

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Ingia / Ingia

Stavaroside K, veratramine and cevine induce hemolysis, whereas 7 other pregnane stavarosides and 8 Veratrum alkaloids are not hemolytic. On the other hand, erythrocytes pretreated or incubated with low concentrations of stavarosides D-F or with the 8 other Veratrum alkaloids were resistant to

[Determination of jervine and veratramine in Veratrum plants using high performance liquid chromatography coupled with evaporative light scattering detection].

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Ingia / Ingia

A method of reversed-phase high performance liquid chromatography (HPLC) coupled with evaporative light scattering detection (ELSD) was developed for the determination of jervine and veratramine in veratrum plants. The extraction method of total active alkaloids from the raw material was also

Studies on veratrum alkaloids. XXIV. The inhibition by veratramine and veratrosine of the cardioaccelerator effect of electrical stimulation of the accelerator nerves.

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Ingia / Ingia

Studies on veratrum alkaloids. Metabolic action of veratridine and of the secondary amine bases veratramine, veratrosine, and pseudo-jervine on cardiac tissue of the rat.

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Ingia / Ingia

Studies on veratrum alkaloids. XV. The quininelike effect of veratramine upon the single twitch and upon the "veratrine response" of the sartorius muscle of the frog.

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Ingia / Ingia

STUDIES ON VERATRUM ALKALOIDS. 38. THE EFFECTS OF 1-ETHOMOXANE AND OF VERATRAMINE ON ISOLATED MAMMALIAN AND INVERTEBRATE HEARTS AND ON THE ISOLATED GUINEA-PIG ILEUM.

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Ingia / Ingia

Studies on veratrum alkaloids. XIV. The antiaccelerator cardiac action of derivatives of veratramine and jervine and of synthetic steroid secondary alkamines obtained from pregnenolone and from sapogenins.

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Ingia / Ingia

Studies on veratrum alkaloids. XVI. The action of epinephrine and of veratramine on the functional refractory period of the auriculo-ventricular transmission in the heart-lung preparation of the dog.

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Ingia / Ingia

STUDIES ON VERATRUM ALKALOIDS. XXXVII. CHRONOTROPIC CARDIAC ACTION AND TOXICITY OF N-ALKYL DERIVATIVES OF VERATRAMINE.

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Ingia / Ingia

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