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Prophylactic White Cell Transfusions Versus Therapeutic White Cell Transfusions in Patients With Leukemia

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Ingia / Ingia

Study Groups: If you are found to be eligible to take part of this study, and you are 1 of the first 60 participants to be enrolled, you will be randomly assigned (as in the flip of a coin) to 1 of 2 groups: - If you are in Group 1, you will receive the standard of care drugs that are used to

Relation of White Blood Cell Function to Diabetes

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Ingia / Ingia

Type II diabetes mellitus is rapidly becoming a global pandemic with a deleterious impact on cardiovascular morbidity and mortality. Understanding its pathophysiology is important for the development of future therapeutic interventions. Interestingly, mitochondrial dysfunction in skeletal muscle and

Therapeutic Effect of Two Fluoride Varnishes on White Spot Lesions: a Clinical Study

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Ingia / Ingia

The aim of this study was to evaluate the therapeutic effect of two varnish formulations (G1 = NaF, 2.26%F, G2 = NaF, 2.71% F + CaF2) on the remineralization of white spot lesions (WSL). The sample was composed of 15 (7- to 12-year-old) children with 45 active WSL in anterior permanent teeth. The

Therapeutic Effects of Maternal Melatonin Administration on Brain Injury and White Matter Disease

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Ingia / Ingia

Neurocognitive sequelae observed in preterm represent a major health problem for which there is no preventive treatment approved to date. These effects are the result of a multifactorial brain damage occurring in developing prenatal and perinatal period. Melatonin, the principal hormone secreted by

A Feasibility Study of Prophylactic White Blood Cell Transfusions

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Ingia / Ingia

Study Procedures: During each white blood cell transfusion, you will receive white blood cells from a volunteer donor through a needle in your vein. Each transfusion will take anywhere from 1 hour to several hours, depending on how you tolerate the treatment. You will receive a transfusion

Hd-bronchoscopy, Comparison to Standard White Light and Autofluorescence Bronchoscopy

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Ingia / Ingia

Rationale Bronchoscopy is one of the most important procedures in diagnosis of lung cancer and other pulmonary diseases. This procedures renders important anatomical information and subtle changes in the epithelium or vascularity of the bronchial tree are clues to guide the endoscopist in this

Reminerlization Potential of Innovative Biomimetic Material in Caries White Spot Lesions

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Ingia / Ingia

Dental caries is the localized destruction of tooth tissues by acids, especially lactic acid, produced by the fermentation of dietary carbohydrates by bacteria in dental plaque. Demineralization can be arrested or reversed when remineralization agents are applied to incipient carious or

Cultured White Cells Plus Interleukin-2 to Treat Advanced Kidney Cancer

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Ingia / Ingia

Background: One area of therapeutic advancement in immunotherapy has been to identify autologous tumor-reactive T-cells and expand them in vitro, and administer them in adoptive transfer back to patients. These T-cells have been obtained either from tumor infiltrating lymphocytes (TIL) which appear

BHS4 - Bone/Muscle Changes Following Hip Fracture in Older White Women

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Ingia / Ingia

Hip fracture is a major public health problem, with striking consequences for the older patient, her family and the health care system. More than 350,000 persons over age 65 will fracture a hip in the United States during the coming year at an estimated annual cost of over $12 billion; by 2040, over

White Blood Cell Counts and Onset of Cardiovascular Diseases: a CALIBER Study

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Ingia / Ingia

There is evidence from epidemiological studies that counts of some types of white blood cell, such as neutrophils, are associated with increased incidence of coronary disease. Associations with other initial presentations of cardiovascular diseases have not been studied in large cohorts, but may be

Imaging Study of the White Matter Lesions in Children With Metachromatic Leucodystrophy

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Ingia / Ingia

Metachromatic Leukodystrophy (MLD) is a rare autosomal recessive disorder caused by the deficiency of the Arylsulfatase A enzyme (ARSA), resulting in accumulation of galactosyl sulfatide (cerebroside sulfate), a major constituent of the myelin sheath. Accumulation of sulfatides leads to a

Melanoma Treatment With White Blood Cells That Destroy MART Expressing Tumor Cells

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Ingia / Ingia

Background: - TIL transfer studies in patients with metastatic melanoma following lymphodepletion have resulted in 50 percent objective response rates with a 10-15 percent rate of complete responses. Despite these important clinical findings, adoptive cell transfer has not become widely available

Positron Emission Tomography (PET) to Locate Areas of White Blood Cell Activity

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Ingia / Ingia

This pilot study aims to evaluate the value of Positron Emission Tomography (PET) in assessing the distribution of activated lymphocytes in SLE patients. Systemic lupus erythematosus (SLE), often defined as the prototypical autoimmune disease, is a chronic occasionally life threatening, multisystem

Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions

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Ingia / Ingia

Recently new approaches to spinal cord repair have been successfully established in animal models. Promising therapies for promoting spinal axonal regeneration in man will be available in the near future. Most research in the field is focussed on the lesion itself and the perilesional spinal cord.

Comparison of Filgrastim and Filgrastim SD/01in Boosting White Cell Counts After Intensive Chemotherapy

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Ingia / Ingia

Background: - Filgrastim (granulocyte colony-stimulating factor), which is administered by daily subcutaneous injection after cytotoxic chemotherapy, shortens the duration of chemotherapy-induced neutropenia and lowers the risk of infection. - In children treated with dose-intensive chemotherapy,

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