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White Matter Integrity According to BDNF Genotype After Stroke

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Ingia / Ingia

The aims of this study were to investigate plastic changes in the fractional anisotropy (FA) of three motor-related white matter fibers according to the BDNF genotype from 2 weeks to 3 months after stroke onset; one is a the majority of fibers from M1 to medullary oblongata (CST), another is the

A Comparison of Hemorrhagic and Ischemic Strokes Among Blacks and Whites

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Ingia / Ingia

For calendar years 1993-94, 1999, 2005, 2010, and 2015 we will identify every hospitalized or autopsied stroke and transient ischemic attack (TIA) at all regional hospitals in our region. We will also estimate the number of non-hospitalized strokes and TIAs by screening for potential cases at more

Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease

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Ingia / Ingia

Objectives: 1. To investigate the relationship of carotid inflammation, as measured by FDG positron emission tomography (PET) to standardized uptake value in atherosclerotic plaque, with the number of covert brain infarcts. 2. To investigate the relationship of FDG PET standardized uptake value with

White Matter Connections and Memory: the STRATEGIC Study

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Ingia / Ingia

Memory breakdown in older age is a major challenge for medical research, with an increasing burden in personal, societal and fiscal terms. Stroke is an important cause. Memory depends on widespread networks in the brain which are bound together by white matter connections, which essentially act as

White Cell Ratios as Markers of Delirium and Outcome in Acute Ischemic Stroke.

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Ingia / Ingia

Delirium is an acute brain disorder, potentially reversible, commonly occurring in patients with acute ischemic stroke. The pathomechanism of delirium is related to neuroinflammatory process and oxidative stress. Search for readily available diagnostic marker that will aid clinicians in early

Scalp Acupuncture Combined rTMS on Brain White Matter Microstructure of Hemiplegic Patients With Stroke

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Ingia / Ingia

Stroke is one of the common cerebrovascular diseases. With the improvement of medical conditions and treatment technology, the death rate of stroke patients has declined, but the disability rate has increased. In China about 50%-70% of stroke patients have the residual sequelae such as paralysis,

Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke

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Ingia / Ingia

Objective: To follow a cohort of stroke patients with white matter hyperintensities (WMH), using MRI, and thereby track the natural history of changes in blood-brain barrier (BBB) disruption. By establishing a better understanding of the relationship between the presence of BBB disruption and WMH

Coronary Heart Disease Risk Factors in Upwardly Mobile Blacks and Whites

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Ingia / Ingia

BACKGROUND: Hypertension related diseases are major causes of morbidity and mortality among United States Blacks. Among Blacks and whites, lower levels of education are associated with higher levels of blood pressure, stroke, and coronary heart disease mortality. High levels of blood pressure in

White Blood Cell Counts and Onset of Cardiovascular Diseases: a CALIBER Study

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Ingia / Ingia

There is evidence from epidemiological studies that counts of some types of white blood cell, such as neutrophils, are associated with increased incidence of coronary disease. Associations with other initial presentations of cardiovascular diseases have not been studied in large cohorts, but may be

Pre-Clinical White Matter Changes and Associated Connectivity Effects in Fabry Disease

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Ingia / Ingia

Fabry disease (FD) is a lysosomal storage disease caused by a deficiency in an enzyme that degrades components of the outer cell wall. A deficiency of this enzyme in humans has been associated with stroke. In males with FD, 6.9% have a stroke by 39 years of age. In females with FD, 4.3% have a

Application of Diffusion Tensor Imaging in Alzheimer's Disease :Quantification of White Matter Micro-structural Changes

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Ingia / Ingia

Alzheimer's disease (AD) is the most common cause of dementia in the elderly, accountings for 60-70% of all demented cases. It is a neuro-pathological diagnosis determined by presence of neurofibrillary tangles and senile plaques in the brain of patients with dementia. The disease frequently starts

White Matter Hyperintensities Subtypes in Cerebral Small Vessel Disease : 7 Tesla Ultra-high Resolution Imaging MRI

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Ingia / Ingia

Amyloid and Glucose PET Imaging in Alzheimer and Vascular Cognitive Impairment Patients With Significant White Matter Disease

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Ingia / Ingia

This study will be a multi-center trial to be conducted in centers across Canada and approximately 80 patients will be enrolled. Participants will be recruited from both stroke prevention (N=40) and memory clinics (N=40). For comparison, we will access the publically-available data using a very

Neural Correlates of Lower Extremity Motor Recovery in Stroke Patients: Longitudinal Diffusion Spectrum Imaging Studies

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Ingia / Ingia

Recent studies have provided strong evidence that motor recovery after adult ischemic stroke is a function of neural plasticity. Up to date, it remains largely unknown as to the relationship between the integrity of the subcortical white matter with the lower extremity function recovery. Given the

The Antidepressant Effects of rTMS After Ischemic Stroke

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Ingia / Ingia

This is a multicenter, randomized, double-blind, placebo-controlled trial aims to assess the effectiveness of rTMS in treating depression after basal ganglia ischemic stroke and to examine whether such effects are related to restoration of white matter integrity.Sixty-six participants will be

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