Grass Sensitisation and Allergic Rhinitis in Thai Patients
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DurumTamamlandı
Sponsorlar
Mahidol University
Ortak çalışanlar
National Research Council of Thailand
KLINIK ÇALIŞMA: NCT01686022
BioSeek: NCT01686022
Anahtar kelimeler
Öz
Allergic rhinitis patients are the patients who have nasal symptoms when triggered by indoor or outdoor allergens. Outdoor allergen can be divided into grass, tree, or weed. The type of grass or weed are different in various part of the world. The allergens from grass and weed has never been studied in Thailand. This study will find the major allergen from Bermuda grass, Johnson grass, Para grass, sedge, and ragweed, which are very common in Thailand. In addition, the investigators will study about the cross-reactivity among these group of allergen.
Açıklama
To find the major allergen of grass and weed, the serum of patients will be used to bind with the allergen extract by immunoblot study.
The ELISA-inhibition will be used to study about cross-reactivity among various kinds of grass and weed.
Tarih
| Son Doğrulandı: | 08/31/2016 |
| İlk Gönderilen: | 09/11/2012 |
| Tahmini Kayıt Gönderildi: | 09/13/2012 |
| İlk Gönderilen: | 09/16/2012 |
| Son Güncelleme Gönderildi: | 09/12/2016 |
| Son Güncelleme Gönderildi: | 09/13/2016 |
| Fiili Çalışma Başlangıç Tarihi: | 09/30/2012 |
| Tahmini Birincil Tamamlanma Tarihi: | 09/30/2015 |
| Tahmini Çalışma Tamamlanma Tarihi: | 09/30/2015 |
Durum veya hastalık
Allergy to Grass Pollen
Allergic Rhinitis Due to Weed Pollens
Müdahale / tedavi
Other: Pollen Allergy
Evre
-
Kol Grupları
| Kol | Müdahale / tedavi |
|---|---|
| Pollen Allergy Pollen allergy and control will have the same intervention, ie. Skin prick test and collect serum samples.Then measure the specificIgE, immunoblot, and ELISA inhibition | Other: Pollen Allergy serum specific IgE binds to grass extract by immunoblot |
Uygunluk kriterleri
| Çalışmaya Uygun Yaşlar | 10 Years İçin 10 Years |
| Çalışmaya Uygun Cinsiyetler | All |
| Örnekleme yöntemi | Non-Probability Sample |
| Sağlıklı Gönüllüleri Kabul Ediyor | Evet |
| Kriterler | Inclusion Criteria: - Allergic rhinitis patients age 10-50 years old - Control: healthy volunteer age 18-50 years old Exclusion Criteria: - Chronic illness such as cardiovascular diseases, liver diseases - History of anaphylaxis - Pregnancy |
