Peroxisomal Defects and Familial Risk for Bipolar Disorder
Anahtar kelimeler
Öz
Açıklama
Overall Study Design: This study entails collecting fasting venous blood (20 ml) from, and administering the 'omega-3 questionnaire' to, subjects being recruited from ongoing National Institute of Mental Health (NIMH)-sponsored trials within the Department of Psychiatry, University of Cincinnati College of Medicine. Specifically, blood will be collected from 20 healthy controls (i.e., no personal or family history of any Axis I mood disorder according to the Diagnostic and Statistical Manual of Mental Disorders-IV [DSM-IV]) and 20 asymptomatic high-risk (i.e., have a biological parent with BD-I) adolescents (aged 10-18 years old) recruited for study MH077138 (UC-IRB #: 07-04-10-03, BITREC Project 3; PI: DelBello), 20 ultra-high risk (i.e., have a biological parent with BD-I and a Major Depressive Disorder (MDD) diagnosis) recruited for study MH083924 (UC-IRB #: 04-09-15-03, CO-Principal Investigators DelBello/McNamara), and 20 adolescents who are admitted for their first hospitalization and who have a diagnosis of BD-I recruited for study MH080973 (UC-IRB #: 08-10-30-01, Principal Investigator: DelBello). Blood will then be processed, and de-identified tubes sent to the Kennedy Krieger Institute, Peroxisomal Diseases Section, to determine the following measures of peroxisomal function: (1) plasma very long chain fatty acids (C24:0 & C26:0) concentrations, (2) plasma bile acid C27 intermediate (dehydrocrepenynic acid {DHCA},tetrahydrocannabinolic acid {THCA})concentrations, (3) plasma pipecolic acid concentrations, and (4) Red Blood Cell (RBC) plasmalogen concentrations. Additionally, RBC fatty acid composition will be determined by gas chromatography, and platelet function and plasma inflammatory markers assayed using commercially available kits according to manufacturer's instructions.
Tarih
Son Doğrulandı: | 11/30/2014 |
İlk Gönderilen: | 10/20/2010 |
Tahmini Kayıt Gönderildi: | 11/04/2010 |
İlk Gönderilen: | 11/08/2010 |
Son Güncelleme Gönderildi: | 12/18/2014 |
Son Güncelleme Gönderildi: | 12/22/2014 |
Fiili Çalışma Başlangıç Tarihi: | 09/30/2010 |
Tahmini Birincil Tamamlanma Tarihi: | 09/30/2013 |
Tahmini Çalışma Tamamlanma Tarihi: | 09/30/2013 |
Durum veya hastalık
Evre
Kol Grupları
Kol | Müdahale / tedavi |
---|---|
Health Controls | |
Bipolar Patients with High-Risk of Mania | |
Bipolar Patients with Ultra-High Risk | |
First Manic Episode Bipolar Youth |
Uygunluk kriterleri
Çalışmaya Uygun Yaşlar | 10 Years İçin 10 Years |
Çalışmaya Uygun Cinsiyetler | All |
Örnekleme yöntemi | Probability Sample |
Sağlıklı Gönüllüleri Kabul Ediyor | Evet |
Kriterler | Subject characteristics: All subjects will be 10-18 year old males and females. Up to 80 patients will be enrolled in this study. Subjects will be screened according to previously approved individual study criteria (UC-IRB #: 07-04-10-03; 04-09-15-03; 08-10-30-01). Inclusion Criteria: - 10 -18 year old males & females - Based on currently enrolled study. Exclusion Criteria: - Based on currently enrolled study. |
Sonuç
Birincil Sonuç Ölçütleri
1. Youth with an elevated risk for developing BD-I and first-episode manic patients will exhibit graded deficits in measures of peroxisomal function compared with healthy controls. [1 day]
İkincil Sonuç Ölçütleri
1. peroxisomal function will be inversely correlated with manic and depression symptom severity scores. [1 day]
2. Indices of peroxisomal function will be correlated with RBC DHA composition. [1 day]