Gender Influence on Torsadogenic Actions of Droperidol.
Anahtar kelimeler
Öz
Tarih
Son Doğrulandı: | 04/30/2019 |
İlk Gönderilen: | 01/29/2019 |
Tahmini Kayıt Gönderildi: | 05/07/2019 |
İlk Gönderilen: | 05/08/2019 |
Son Güncelleme Gönderildi: | 05/09/2019 |
Son Güncelleme Gönderildi: | 05/13/2019 |
Fiili Çalışma Başlangıç Tarihi: | 04/22/2019 |
Tahmini Birincil Tamamlanma Tarihi: | 11/30/2020 |
Tahmini Çalışma Tamamlanma Tarihi: | 11/30/2020 |
Durum veya hastalık
Müdahale / tedavi
Drug: Droperidol group
Evre
Kol Grupları
Kol | Müdahale / tedavi |
---|---|
Other: Droperidol group Droperidol (Xomolix, Kyowa Kirin) 1.25 mg i.v. bolus | Drug: Droperidol group An electrocardiogram analysis in: 5,10,15,20 minutes after injection of 1.25 mg of droperidol used as PONV prophylaxis. |
Uygunluk kriterleri
Çalışmaya Uygun Yaşlar | 18 Years İçin 18 Years |
Çalışmaya Uygun Cinsiyetler | All |
Sağlıklı Gönüllüleri Kabul Ediyor | Evet |
Kriterler | Inclusion Criteria: - age between 18 and 45 years old - ASA (American Society of Anaesthesiologists) physical status 1 and 2 Exclusion Criteria: - lack of informed consent - ASA (American Society of Anaesthesiologists) physical status 3 and more - admittance of repolarisation affecting drugs like: antiarrhythmics (Williams group I-IV), psychotropics, macrolides, antireflux drugs - ischaemic heart disease - cardiac failure NYHA (Hew York Heart Association) 1 and more - congenital or acquired heart defects - arrhythmias in anamnesis - hormonal contraception, - postmenopausal - neoplasms |
Sonuç
Birincil Sonuç Ölçütleri
1. QT and corrected QT interval time [Change from baseline QT and corrected QT interval time at 5,10,15 and 20 minutes after administration of 1.25 mg droperidol]
2. Time interval between T wave peak and T wave end [Change from baseline T peak - T end time at 5,10,15 and 20 minutes after administration of 1.25 mg droperidol.]