Olfactory Dysfunction of Rhinosinusitis
Anahtar kelimeler
Öz
Açıklama
This is a prospective cohort study. Subjects will be recruited from the group of patients at the University of Washington Otolaryngology-Head and Neck Surgery Clinic who will undergo endoscopic sinus surgery for chronic sinusitis and other disorders of the nasal cavity and sinuses.
Subjects will sign consent and complete a subjective smell test (UPSIT--University of Pennsylvania Smell Identification Test), and the SNOT-20 (Sinonasal Outcome Test-20)
During their surgery, subjects will have two to four pieces of normally discarded tissue preserved for the study. Subjects will also have two to four pieces of healthy tissue removed (total size approximately that of a pencil eraser tip)depending on the type of surgery involved. The following procedures will be performed on these tissues:
- immunocytochemistry utilizing antibodies to AC3 and Golf to determine the patterns and levels of expression of these proteins
- two odorants, isoamyl acetate and citralva, to elicit odorant-induced activity from the human olfactory sensory neurons. The tissue will also be subjected to two putative human pheromones: 4,16-androstadiene-3-ol and 1,3,5(10),16-estrateraen-3-ol.
- application of six commonly used intranasal agents: 0.9% saline, 1:1000,000 epinephrine, 0.05% oxymetazoline, 1% lidocaine, Zicam (0.12% zinc gluconate) and Nasocort AQ (triamcinolone acetate).
Tarih
Son Doğrulandı: | 05/31/2012 |
İlk Gönderilen: | 11/20/2008 |
Tahmini Kayıt Gönderildi: | 11/20/2008 |
İlk Gönderilen: | 11/23/2008 |
Son Güncelleme Gönderildi: | 06/26/2012 |
Son Güncelleme Gönderildi: | 06/28/2012 |
Fiili Çalışma Başlangıç Tarihi: | 10/31/2008 |
Tahmini Birincil Tamamlanma Tarihi: | 08/31/2010 |
Tahmini Çalışma Tamamlanma Tarihi: | 08/31/2010 |
Durum veya hastalık
Evre
Kol Grupları
Kol | Müdahale / tedavi |
---|---|
endoscopic sinus procedure candidates |
Uygunluk kriterleri
Çalışmaya Uygun Yaşlar | 18 Years İçin 18 Years |
Çalışmaya Uygun Cinsiyetler | All |
Örnekleme yöntemi | Non-Probability Sample |
Sağlıklı Gönüllüleri Kabul Ediyor | Evet |
Kriterler | Inclusion Criteria: - over 18 yrs. of age, scheduled for: a.) endoscopic sinus surgery for chronic sinusitis, b.) endoscopic transnasal approach to the pituitary for pituitary tumor removal, c.) endoscopic inferior turbinectomy for nasal congestion d.)endoscopic repair of cerebrospinal fluid leaks Exclusion Criteria: - unable to give informed consent or complete questionnaires due to language, cognitive impairment or sever medical conditions. |