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Variables Predicting Reintubation After Thymectomy in Patients With Myasthenia Gravis

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First Affiliated Hospital, Sun Yat-Sen University

Anahtar kelimeler

Öz

Myasthenia gravis (MG) is an autoimmune disease that is characterized by muscle weakness and fatigue. The role of the thymus in MG has been suggested by the evidence that 10% to 15% of patients present with a thymoma and at least 60% with thymus hyperplasia or dysplasia.Beneficial effects of thymectomy in patients with MG have been described in 40% to 90%.Few studies have looked at the incidence of reintubation (not just within 24 hours after extubation), the factors associated with reintubation, and patient outcome.
Premature extubation may lead to hypercarbia, hypoxemia, pulmonary hypertension, right heart failure, and myocardial ischemia. Additionally, it subjects the patient to the physical risks of reintubation, including esophageal intubation, laryngeal trauma, and pulmonary aspiration. The purpose of the present study was to determine the incidence of reintubation, the variables associated with reintubation, and patient outcome

Açıklama

Inclusion was based on the availability of all the following possible predictive pre-operative variables: age, gender, weight, height, body mass index, diabetes, creatinine, duration of MG, severity of MG (based on Osserman's classification), pathological type of MG, history of myasthenic crisis, dose of pyridostigmine, use of a steroid hormone, and use of an immunosuppressant.operative variables: postoperative pulmonary infection, total duration of hospital stay, duration of ICU stay, and duration of postoperative hospital stay. Variables were collected by research assistants and maintained in a computer database.

Tarih

Son Doğrulandı: 06/30/2018
İlk Gönderilen: 07/12/2018
Tahmini Kayıt Gönderildi: 07/19/2018
İlk Gönderilen: 07/23/2018
Son Güncelleme Gönderildi: 07/19/2018
Son Güncelleme Gönderildi: 07/23/2018
Fiili Çalışma Başlangıç Tarihi: 12/31/2016
Tahmini Birincil Tamamlanma Tarihi: 12/31/2018
Tahmini Çalışma Tamamlanma Tarihi: 12/31/2018

Durum veya hastalık

Myasthenia Gravis

Müdahale / tedavi

Other: reintubation

Evre

-

Kol Grupları

KolMüdahale / tedavi
reintubation
Reestablish of invasive mechanical ventilation
not reintubation
Favourable respiratory function

Uygunluk kriterleri

Çalışmaya Uygun Yaşlar 18 Years İçin 18 Years
Çalışmaya Uygun CinsiyetlerAll
Örnekleme yöntemiProbability Sample
Sağlıklı Gönüllüleri Kabul EdiyorEvet
Kriterler

Inclusion Criteria:

- younger than 75 years

- absence of heart failure as the primary indication for mechanical ventilation •Acute Physiology and Chronic Health Evaluation (APACHE) II score less than 12 points on day of extubation

- body mass index less than 30

Exclusion Criteria:

•preoperative moderate-to-severe chronic obstructive pulmonary disease

Sonuç

Birincil Sonuç Ölçütleri

1. Risk Factors for Reintubation [an average of 30 days]

the reintubation rate was analyzed with logistic regression

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  • 55 dilde çalışır
  • Bilim destekli bitkisel kürler
  • Görüntüye göre bitki tanıma
  • Etkileşimli GPS haritası - bölgedeki bitkileri etiketleyin (yakında)
  • Aramanızla ilgili bilimsel yayınları okuyun
  • Şifalı bitkileri etkilerine göre arayın
  • İlgi alanlarınızı düzenleyin ve haber araştırmaları, klinik denemeler ve patentlerle güncel kalın

Bir belirti veya hastalık yazın ve yardımcı olabilecek bitkiler hakkında bilgi edinin, bir bitki yazın ve karşı kullanıldığı hastalıkları ve semptomları görün.
* Tüm bilgiler yayınlanmış bilimsel araştırmalara dayanmaktadır

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