Circadian pattern of acute, neuroleptic-induced dystonic reactions.
Anahtar kelimeler
Öz
OBJECTIVE
This study examined the timing of acute dystonic reactions in 200 patients taking neuroleptic medication for the first time.
METHODS
Two hundred patients received a twice-daily regimen of low-dose neuroleptic.
RESULTS
Over 80% of the episodes of acute dystonia occurred between 12:00 noon and 11:00 p.m. The observed circadian variation was not accounted for by sleep, fatigue, or time elapsed from the last dose of medication.
CONCLUSIONS
The finding of a diurnal pattern in one of the recognized side effects of neuroleptic medication suggests that the therapeutic efficacy of neuroleptics might similarly vary over the course of the day.