Zhongguo Zhongyao Zazhi 2011-Apr
[Effects of glycyrrhiza extract on pharmacokinetics property of daphnetin in rats].
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OBJECTIVE
To research the influence of glycyrrhiza extract on the pharmacokinetics characteristic parameters of daphnetin, which was aimed to explore the rationality of concert application of drugs.
METHODS
The rats received intragastric administration of daphnetin and glycyrrhiza extract containing the same daphnetin respectively. The blood concentration of daphnetin was assayed by LC-MS. The data was processed by program DAS2.1.1.
RESULTS
Glycyrrhiza extract can reduce the t(1/2), tmax and Ke of daphnetin, while increased the Ka and AUC(0-infinity).
CONCLUSIONS
Glycyrrhiza extract promoted the oral absorption of daphnetin, slowed down the elimination and increased the biological availability.
