4 demethyl epipodophyllotoxin/kanser

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Inhibition of NADH-linked respiration with the anti-cancer agent 4'-demethyl-epipodophyllotoxin thenylidene glucoside (VM-26).

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Chemopreventive effect of 4'-demethyl epipodophyllotoxin on DMBA/TPA-induced mouse skin carcinogenesis.

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The chemopreventive effect of topical application of 4'-demethyl epipodophyllotoxin (DMEP), an antimitotic agent, on a two-stage skin carcinogenesis model in Swiss Albino mice induced by 9, 10-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) was investigated. Two topical

In vitro test-system for chemo- and thermosensitivity: an analysis of survival fractions and cell-cycle distributions in human Ewing's sarcomas as a modelfor tumors in pediatric oncology.

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BACKGROUND Tumor cell resistance to anticancer drugs is the primary reason for treatment failure in childhood cancer. Resistance can exist at the onset of treatment or can become clinically apparent under selective pressure of drug exposure. In vitro predictive tests are important for the

[Japanese-French cooperation in tumor pharmacotherapy: 1970-1990].

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Since 1970, we have carried out cancer chemotherapy and immunotherapy in cooperation with Japanese scientists, particularly Prof. H. Umezawa, who has generously supplied bleomycin, peplomycin, acalcinomycin A (ACM), THP-adriamycin (THP), neothramycin and bestatin. Malignant tumors curable by

Chemotherapy of primary malignant brain tumors in children.

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Numerous investigators have reported on a variety of chemotherapeutic agents tested in children suffering from recurrent medulloblastoma, brain stem glioma, and ependymoma, in efforts to improve survival and reduce morbidity. Evaluation of such studies is difficult, because there were rarely more

Studies in sugar chemistry. VII. Glucuronides of podophyllum derivatives.

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The antitumor activities of several glucuronide methyl esters of podophyllum derivatives were tested in vitro against two human tumor cell lines and their drug resistant sublines. The most active compound studied was methyl (4'-carbobenzoxy-4'-demethyl-epipodophyllotoxin-D-glucopyranoside)uronat e

Status report of Mayo Clinic studies.

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Described are primary treatment protocols for 1) those patients with gorssly unresectable stage III or IV ovarian carcinoma, considered reasonable candidates for therapeutic trials aimed at the identification of antitumor activity as determined by the regression of objectively evaluable lesions; and

GP7 can induce apoptotic DNA fragmentation of human leukemia cells through caspase-3-dependent and -independent pathways.

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GP7 (4-[4"-(2",2",6",6"-tetramethyl-l"-piperidinyloxy)amino]-4'-demethyl epipodophyllotoxin), a new spin-labeled derivative of podophyllotoxin, is a promising anticancer drug of podophyllotoxin class. The primary effect of GP7 is the anticancer activity on transplanted mouse tumors and cultured

New spin labeled analogues of podophyllotoxin as potential antitumor agents.

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Four new nitroxyl labeled derivatives of podophyllotoxin, 4-(2, 2, 6, 6-tetramethyl-1-oxyl-4-piperidyl)oxy-epipodophyllotoxin (4), 4-(2, 2, 6, 6-tetramethyl-1-oxyl-4-piperidyl)oxy-4'-demethylepipodophyllotoxin (5), 4-(2, 2, 5, 5-tetramethyl-1-oxyl-3-pyrrolinyl)formyloxy-epipodophyllotox in (6) and

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