butanedione/atrofi

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[An electrophysiological study on peripheral neurotoxicity of 2,3-butanedione, 2,4-pentanedione and 2,5-hexanedione in rats].

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A series of studies was made to clarify the relationship of the chemical structures of 2,3-butanedione (2,3-BDione), 2,4-pentanedione (2,4-PDione) and 2,5-hexanedione (2,5-HDione) to neurotoxicity in terms of n-hexane neuropathy and relative neurotoxic potentials, using electrophysiological methods.

Prevention of the oxygen paradox in hypoxic-reoxygenated hearts.

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Reoxygenation after 60 min substrate-free hypoxic perfusion (modified Tyrode solution, 37 degrees C) caused isolated Langendorff hearts (from rats) to rapidly develop hypercontracture and sarcolemmal disruptions indicated by massive and sudden loss of enzymes ("oxygen paradox"). Reoxygenation (30

Mechanical activity in heart regulates translation of alpha-myosin heavy chain mRNA but not its localization.

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Mechanical inactivity depresses protein expression in cardiac muscle tissue and results in atrophy. We explore the mechanical transduction mechanism in spontaneously beating neonatal rat cardiomyocytes expressing the alpha-myosin heavy chain (alpha-MyHC) isoform by interfering with cross-bridge

Myosin heavy chain turnover in cultured neonatal rat heart cells: effects of [Ca2+]i and contractile activity.

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Blockade of L-type Ca2+ channels in spontaneously contracting cultured neonatal rat ventricular myocytes causes contractile arrest, myofibrillar disassembly, and accelerated myofibrillar protein turnover. To determine whether myofibrillar protein turnover. To determine whether myofibrillar atrophy

Contraction of tubulointerstitial fibrosis tissue in diabetic nephropathy, as demonstrated in an in vitro fibrosis model.

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Tubulointerstitial fibrosis in diabetic nephropathy (DN) was investigated using an in vitro tissue model of remodeling, to determine the pathogenic mechanism of fibrosis that leads to renal atrophy, i.e., renal failure. The remodeling model consisted of a renal fibroblast-populated collagen lattice

Incorporation of stable organic radicals of the tris(2,4, 6-trichlorophenyl)methyl radical series to pyrrole units as models for semiconducting polymers with high spin multiplicity. 1.

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The condensation reactions between (4-amino-2,6-dichlorophenyl)bis(2, 4,6-trichlorophenyl)methyl radical and acetylacetone or 1, 4-bis(5-methyl-2-thienyl)-1,4-butanedione yield [2,6-dichloro-4-(2, 5-dimethyl-1-pyrrolyl)phenyl]bis(2,4,6-trichlorophenyl)methyl radical (3(*)()) and [2,6-dichloro-4-[2,

Differences in the structural characteristics of adult guinea pig and rat cardiomyocytes during their adaptation and maintenance in long-term cultures: confocal microscopy study.

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In this study, we used laser confocal scanning microscopy and immunofluorescent markers to describe the establishment of long-term (1-5 week) cultures of adult guinea pig cardiomyocytes and adult rat cardiomyocytes. Providing that the preparation of freshly isolated guinea pig cardiomyocytes

Formation and migration of α-dicarbonyl compounds during storage and reheating of a sugary food simulation system.

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Thermal processing of food results in the formation of α-dicarbonyl compounds (α-DCs) such as glyoxal (GO), methylglyoxal (MGO), 2,3-butanedione (2,3-BD) and 3-deoxyglucosone (3-DG), which are precursors of potentially harmful advanced glycation end products. Some of the α-DCs found in

Color, lipid oxidation, sensory quality, and aroma compounds of beef steaks displayed under different levels of oxygen in a modified atmosphere package.

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High oxygen modified atmosphere packaging (MAP) is currently used by the industry to maintain an attractive color in fresh meat. However, it can also promote lipid oxidation and sensory changes. The aim of this study was to compare the quality of beef steaks displayed under different levels of

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