butanedione/kanser

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Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines.

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N'-Nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are carcinogenic tobacco-specific nitrosamines believed to play a vital role in the initiation of tobacco-related cancers. For their carcinogenicities to be exhibited, both NNN and NNK must be metabolically

Chemokines regulate cellular polarization and adhesion receptor redistribution during lymphocyte interaction with endothelium and extracellular matrix. Involvement of cAMP signaling pathway.

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Leukocyte recruitment is a key step in the inflammatory reaction. Several changes in the cell morphology take place during lymphocyte activation and migration: spheric-shaped resting T cells become polarized during activation, developing a well defined cytoplasmic projection designated as cellular

Spectral, thermal, molecular modeling and biological studies on mono- and binuclear complexes derived from oxalo bis(2,3-butanedionehydrazone).

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BACKGROUND Hydrazones and their metal complexes were heavily studied due to their pharmacological applications such as antimicrobial, anticonvulsant analgesic, anti-inflammatory and anti-cancer agents. This work aims to synthesize and characterize novel complexes of VO(2+), Co(2+), Ni(2+), Cu(2+),

Versatile rare-earth oxide nanocomposites: enhanced chemo/photothermal/photodynamic anticancer therapy and multimodal imaging.

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The development of novel nanocomposites that combine multiple imaging and therapeutic strategies has recently attracted considerable attention because of their cumulative and synergistic therapeutic effects. In this study, doxorubicin (DOX)- and indocyanine green (ICG)-loaded

Smart All-in-One Thermometer-Heater Nanoprobe Based on Postsynthetical Functionalization of a Eu(III)-Metal-Organic Framework.

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Real-time temperature feedback in tissue based on photothermal therapy is an urgent problem to be solved in cancer treatment. Herein, a smart all-in-one nanoprobe THA@Eu-NMOF@Fe/TA was designed and assembled by postsynthetical functionalization of an Eu(III)-based nanoscale metal-organic framework

Action of copper(II) complex with β-diketone and 1,10-phenanthroline (CBP-01) on sarcoma cells and biological effects under cell death.

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This work reports the biological evaluation of a copper complex of the type [Cu(O-O)(N-N)ClO₄], in which O-O = 4,4,4-trifluoro-1-phenyl-1,3-butanedione (Hbta) and N-N = 1,10-phenanthroline (phen), whose generic name is CBP-01. The cytotoxic effect of CBP-01 was evaluated by resazurin

Intracellular delivery and antitumor effects of pH-sensitive liposomes based on zwitterionic oligopeptide lipids.

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pH-sensitive liposomes (HHG2C(18)-L and PEGHG2C(18)-L) based on zwitterionic oligopeptide lipids as anticancer drug carriers were developed and evaluated for effective intracellular delivery and enhanced antitumor activity. The amino acid-based lipids, 1,5-dioctadecyl-l-glutamyl

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