choroidal neovascularization/glutathione

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Protective role of glutathione peroxidase 4 in laser-induced choroidal neovascularization in mice.

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OBJECTIVE To evaluate the influence of glutathione peroxidase 4 (GPx4) expression in retinal pigment epithelium (RPE)/choroid tissue using a mouse model of laser-induced choroidal neovascularization (CNV). METHODS In this study, GPx4+/-, GPx4+/+, and GPx4-overexpressing transgenic mice were created

Suppression of choroidal neovascularization by N-acetyl-cysteine in mice.

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OBJECTIVE N-acetyl-cysteine (NAC) is a potent antioxidant known to be a precursor of glutathione. The purpose of this study was to investigate the role of NAC in the development of choroidal neovascularization (CNV). METHODS CNV was induced in C57BL/6 mice by laser photocoagulation of the ocular

Induction of vascular endothelial growth factor by 4-hydroxynonenal and its prevention by glutathione precursors in retinal pigment epithelial cells.

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Although 4-hydroxynonenal, a highly reactive lipid peroxidation product, is implicated in several age-related disorders such as Alzheimer's and Parkinson's diseases, its role in age-related macular degeneration is not known. The purpose of this study was to determine whether 4-hydroxynonenal

Plasma homocysteine and total thiol content in patients with exudative age-related macular degeneration.

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OBJECTIVE Exudative age-related macular degeneration (ARMD) is one of the debilitating ocular complications, which results in permanent blindness. Elevated homocysteine (Hcys) levels have been associated in the development of several vascular diseases. Vascular and oxidative stress theories have

Plasma oxidized LDL and thiol-containing molecules in patients with exudative age-related macular degeneration.

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OBJECTIVE It was proposed that total thiols (tSH) as powerful reducing agents and oxidized low-density lipoprotein (OX-LDL) may be associated with development of choroidal neovascularization in exudative age-related macular degeneration (E-ARMD). METHODS In a case-control study, 45 patients with

Proteomic profiling of human retinal and choroidal endothelial cells reveals molecular heterogeneity related to tissue of origin.

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OBJECTIVE The ocular vascular endothelium plays a key role in the development of several leading retinal causes of blindness in Western nations. Choroidal endothelial cells are integral to the subretinal neovascular lesions that characterize the exudative form of late age-related macular

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Herbal & Natural Medicine

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