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Intraperitoneal endotoxin but not protein malnutrition shifts d-tubocurarine dose-response curves in mouse gastrocnemius muscle.

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Burn injury-induced changes at the neuromuscular junction include muscle weakness and altered response to neuromuscular blocking drugs. Protein malnutrition and sepsis can concomitantly occur with burn trauma. The role of pure malnutrition or sepsis, in the absence of burn injury, in inducing

Impairment of synaptic vesicle exocytosis and recycling during neuromuscular weakness produced in mice by 2,4-dithiobiuret.

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Chronic treatment of rodents with 2,4-dithiobiuret (DTB) induces a neuromuscular syndrome of flaccid muscle weakness that mimics signs seen in several human neuromuscular disorders such as congenital myasthenic syndromes, botulism, and neuroaxonal dystrophy. DTB-induced muscle weakness results from

Stapedius reflex in curarized subjects: an index of neuromuscular weakness.

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To examine the validity of the acoustical stapedial reflex (AR) as an index of neuromuscular weakness, the AR was measured along with other indices of muscle strength during administration of d-tubocurarine (dTc) to six healthy subjects. AR decreased immediately after each dTc dose and preceded

Cough dynamics during progressive expiratory muscle weakness in healthy curarized subjects.

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The dynamics of voluntary cough were studied in healthy supine subjects during four successive infusions of d-tubocurarine (dTc) (0.05 mg/kg) to assess the effects of progressive expiratory muscle weakness on cough performance. Curarization produced a progressive decline in maximal static expiratory

Acoustic reflex response during curare-induced weakness.

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The acoustic stapedial reflex (AR) was measured in five healthy subjects during intravenous administration of d-tubocurarine in four equal doses totaling 0.2 mg/kg. The behavior of the reflex in the face of progressive muscle weakness was assessed. Amplitude changes in the AR elicited by pulsed

Analysis of the organophosphate-induced electromyographic response to repetitive nerve stimulation: paradoxical response to edrophonium and D-tubocurarine.

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We studied the mechanism underlying acute organophosphate intoxication (OPI) through in-vivo and in-vitro electrophysiologic studies in rats injected with diisopropylfluorophosphate. Intoxicated rats showed weakness, repetitive compound muscle action potentials (CMAPs) in response to a single

Effect of respiratory muscle weakness on P0.1 induced by partial curarization.

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Mouth occlusion pressure 0.1 s after onset of inspiration (P0.1) reflects central respiratory drive (CRD), but its dependence on respiratory muscle strength is unknown. To clarify this relationship, we produced progressive levels of respiratory muscle weakness by infusion of d-tubocurarine in eight

Autoimmune aetiology for acquired neuromyotonia (Isaacs' syndrome)

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Neuromyotonia is a rare disorder of unknown cause in which hyperexcitability of peripheral motor nerves leads to incapacitating muscle twitching, cramps, and weakness. We investigated an antibody-mediated mechanism for neuromyotonia in a 24-year-old man with a 7-year history of severe disease

The Facilitatory Effect of Casearia sylvestris Sw. (guaçatonga) Fractions on the Contractile Activity of Mammalian and Avian Neuromuscular Apparatus.

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Many natural products influence neurotransmission and are used clinically. In particular, facilitatory agents can enhance neurotransmission and are potentially useful for treating neuromuscular diseases in which muscular weakness is the major symptom. In this work, we investigated the facilitatory

The facilitatory effect of Casearia sylvestris Sw. (guaçatonga) fractions on the contractile activity of mammalian and avian neuromuscular apparatus.

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Effect of curare on maximum static PV relationships of the respiratory system.

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The effect of respiratory muscle weakness on the maximum static pressure-volume (PV) characteristics of the respiratory system was studied in four healthy males infused slowly with d-tubocurarine (dtc). Inspiratory capacity (IC), expiratory reserve volume (ERV), maximum static inspiratory and

Susceptibility to murine experimental autoallergic myasthenia gravis: the role of antibody specificity.

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To examine the differing susceptibility of C57BL/6J and C3H/HeJ mice to experimental autoallergic myasthenia gravis (EAMG), we have compared the pathogenicity of sera from the two strains. Mice were immunized with acetylcholine receptor from T. californica and muscle weakness assessed as the time

Diaphragmatic function in healthy subjects during partial curarization.

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Diaphragmatic function estimated by transdiaphragmatic pressure (Pdi) was studied in eight normal subjects during progressive partial paralysis with d-tubocurarine (dTc). Dynamic Pdi was measured during quiet tidal breathing, maximum deep inspiration, and 12-s maximum voluntary ventilation (MVV).

Respiratory mechanics in supine subjects during progressive partial curarization.

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Respiratory mechanics were studied in six supine conscious volunteers during progressive muscle weakness produced by infusion of d-tubocurarine. Partial curarization was carried out to the point of abolishing head lift ability and handgrip strength. At all levels of partial paralysis, expiratory

Motor dysfunction in thymoma rats: comparison between fast and slow muscles.

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Buffalo/Mna rats (Mna rats) with spontaneous thymoma show the motor dysfunction represented by an exacerbated fatigability of hind-limb muscles. In this study fast (extensor digitorum lomgus, EDL) and slow (soleus) muscles of these rats were examined physiologically and pharmacologically. ACI strain

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