elecampane/antioksidan

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Temporal, Plant Part, and Interpopulation Variability of Secondary Metabolites and Antioxidant Activity of Inula helenium L.

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Variations in abiotic environmental factors have significant effects on quantity and quality of secondary metabolites, which is particularly important for plant species that possess biologically active compounds. The purpose of this study is determination of the total phenolic content, flavonoid

Comparative effects of n-hexane and methanol extracts of elecampane (Inula helenium L.) rhizome on growth performance, carcass traits, feed digestibility, intestinal antioxidant status and ileal microbiota in broiler chickens.

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In this study, the effects of dietary methanol and n-hexane extracts of elecampane rhizome (MEER and HEER, respectively) on growth performance, apparent ileal nutrient digestibility (AID), ileal microbiota, intestinal morphology and antioxidant status of the intestinal mucosa were compared in

Antioxidant and anticancer activities of extract of Inula helenium (L.) in human U-87 MG glioblastoma cell line.

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UNASSIGNED The aim of this study is to explore the antioxidant and antiproliferative activities of aqueous extract from aerial parts of Inula helenium (L.) against human U-87 MG glioma cell line. UNASSIGNED The 3'-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and lactate dehydrogenase

Ultrasound and Microwave-Assisted Extraction of Elecampane (Inula helenium) Roots.

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The aim of the current research was to perform two "green chemistry" extractions (ultrasound and microwave irradiation) with methanol, 70% (v/v) ethanol and water for extraction of biologically active substances from elecampane (Inula heleniun L.) roots and to compare their contents in all extracts.

[Mechanisms of antistressor activity of Inula helenium preparations].

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The antistressor and antioxidant properties of preparations from the underground part of elfwort (Inula helenium) were studied on a model of acute stress in mice. The preparations produced a protective effect with respect to internal organs, blood, carbohydrate metabolism, and lipid peroxidation

Nrf2-mediated induction of detoxifying enzymes by alantolactone present in Inula helenium.

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Our previous study showed that a methanol extract of Inula helenium had the potential to induce detoxifying enzymes such as quinone reductase (QR) and glutathione S-transferase (GST) activity. In this study the methanol extract was further fractionated using silica gel chromatography and vacuum

Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes via JAK/STAT3 signaling.

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This study aimed to evaluate the protective effect of igalan, a sesquiterpene lactone isolated from Inula helenium (L.), on inhibiting inflammation, regulating the epidermal differentiation gene expression, and reactive oxygen species scavenging in atopic dermatitis (AD)-like

Protective Effect of Total Phenolic Compounds from Inula helenium on Hydrogen Peroxide-induced Oxidative Stress in SH-SY5Y Cells.

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Inula helenium has been reported to contain a large amount of phenolic compounds, which have shown promise in scavenging free radicals and prevention of neurodegenerative diseases. This study is to investigate the neuroprotective effects of total phenolic compounds from I. helenium on hydrogen

Antioxidative/acetylcholinesterase inhibitory activity of some Asteraceae plants.

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The extracts obtained by 80% EtOH from some Asteraceae plants (Calendula officinalis, Inula helenium, Arctium lappa, Artemisia absinthium and Achillea millefolium) were studied. Rosmarinic acid, one of the main compounds identified in all extracts, was determined quantitatively by using HPLC. In

Induction of detoxifying enzyme by sesquiterpenes present in Inula helenium.

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Our previous study showed that the methanolic extract of Inula helenium (elecampane) had the potential to induce detoxifying enzymes such as quinine reductase (QR) and glutathione S-transferase. In this study we further fractionated the methanolic extract into hexane-, dichloromethane-, butanol-,

Isoalantolactone from Inula helenium caused Nrf2-mediated induction of detoxifying enzymes.

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Our previous study demonstrated that methanolic extract of Inula helenium (Elecampane) has the potential to induce detoxifying enzymes such as NAD(P)H:(quinone acceptor) oxidoreductase 1 (EC 1.6.99.2) (NQO1, QR) activity and glutathione S-transferase (GST) and found isoalantolactone and

Estimating the yin-yang nature of Western herbs: a potential tool based on antioxidation-oxidation theory.

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BACKGROUND One of the biggest obstacles to progress in traditional Chinese medicine (TCM) development in Western countries is the difficulty of applying the traditional concepts to the Western medicinal plants, which are not traditionally described in ancient literature. During recent years, new

Synthesis and Cytotoxic Activity of Azine Derivatives of 6-Hydroxyxanthanodiene.

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The conjugates of the sesquiterpene lactone of the eremophilane series of 6-hydroxyxanthanodiene with hydrogenated azines (piperidines and piperazines) have been synthesized and identified by NMR spectrometer.A lactone with an unusual skeleton

Activation of Nrf2 by costunolide provides neuroprotective effect in PC12 cells.

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Costunolide (COS) is a natural sesquiterpene lactone originally isolated from Inula helenium (Compositae). Although COS is known for its multiple pharmacological activities, neuroprotection of COS has not been fully elucidated. Increasing evidence demonstrates that oxidative stress is strongly

Isoalantolactone protects LPS-induced acute lung injury through Nrf2 activation.

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Isoalantolactone (ISO), a sesquiterpene lactone isolated from Inula helenium, is known to have anti-inflammatory activity. Here, using a mouse model of acute lung injury, we investigated the effects of ISO on lung inflammation in vivo. ISO (2.5, 5, 10 mg/kg) was administered 1 h before LPS

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