germacrone/curcuma aromatica

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Preparative isolation and purification of germacrone and curdione from the essential oil of the rhizomes of Curcuma wenyujin by high-speed counter-current chromatography.

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High-speed counter-current chromatography (HSCCC) was applied to isolate and purify bioactive compounds in the essential oil of the rhizomes of Curcuma wenyujin. Two sesquiterpenes germacrone and curdione were successfully isolated and purified using two-phase solvent system composed of petroleum

[The volatile oil of zedoaria IV: TLC densitometric determination of germacrone in the essential oils from Curcuma wenyujin and C. kwangsinensis].

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In Vitro Anti-Inflammatory, Anti-Oxidant, and Cytotoxic Activities of Four Curcuma Species and the Isolation of Compounds from Curcuma aromatica Rhizome

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The genus Curcuma is part of the Zingiberaceae family, and many Curcuma species have been used as traditional medicine and cosmetics in Thailand. To find new cosmeceutical ingredients, the in vitro anti-inflammatory, anti-oxidant, and cytotoxic activities of four Curcuma species

New Sesquiterpenoids and Anti-Platelet Aggregation Constituents from the Rhizomes of Curcuma zedoaria.

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Two new sesquiterpenoids-13-hydroxycurzerenone (1) and 1-oxocurzerenone (2)-have been isolated from the rhizomes of Curcuma zedoaria, together with 13 known compounds (3-15). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds,

Cytotoxic constituents from the rhizomes of Curcuma zedoaria.

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Curcuma zedoaria also known as Temu putih is traditionally used in food preparations and treatment of various ailments including cancer. The cytotoxic activity of hexane, dichloromethane, ethyl acetate, methanol, and the methanol-soxhlet extracts of Curcuma zedoaria rhizomes was tested on two human

Anti-inflammatory sesquiterpenes from Curcuma zedoaria.

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From the methanolic extract of the rhizome of Curcuma zedoaria, we isolated anti-inflammatory sesquiterpene furanodiene (1) and furanodienone (2) along with new sesquiterpene compound 3 and known eight sesquiterpenes, zederone (4), curzerenone (5), curzeone (6), germacrone (7), 13-hydroxygermacrone

Germacrone derivatives: synthesis, biological activity, molecular docking studies and molecular dynamics simulations.

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Germacrone is one of the major bioactive components in the Curcuma zedoaria oil product, which is extracted from Curcuma zedoaria Roscoe, known as zedoary. The present study designed some novel germacrone derivatives based on combination principles, synthesized these compounds, and investigated

Transannular cyclization of (4S,5S)-germacrone-4,5-epoxide into guaiane and secoguaiane-type sesquiterpenes.

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Germacrone (1) and (4S,5S)-germacrone-4,5-epoxide (2) were isolated, along with guaiane and secoguaiane-type sesquiterpenes, from Curcuma aromatica plants. Compound 2 was derived from 1 and cyclized through transannular (T-A) reactions into various guaiane and secoguaiane-type sesquiterpenes in C.

Compounds isolated from Curcuma aromatica Salisb. inhibit human P450 enzymes.

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Curcuma species (Zingiberaceae) are used as both food and medicine in Asia. Ten sesquiterpenes (1-10) and two curcuminoids (11 and 12) were isolated from the rhizomes of Curcuma aromatica Salisb. and identified. The compounds were evaluated for their ability to inhibit cytochrome P450 (CYP). Among

[Fingerprints of Curcuma wenyujin by RP-HPLC].

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OBJECTIVE To establish a mutual mode fingerprint of Curcuma wenyujin for quality control of C. wenyujin. METHODS Waters Symmetry C18 column was used; the mobile phase was methanol-water in a linear gradient elution with the flow rate of 1.0 mL/ min, the temperature of column was 30 degrees C; the

[GC-MS analysis of essential oil from Curcuma aromatica rhizome of different growth periods].

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OBJECTIVE To analyze the essential oil from the rhizome of Curcuma aromatica of different growth periods, and to provide the scientific reference for reasonable cultivation and quality control of this plant. METHODS The essential oil was extracted by hydrodistillation and analyzed with GC-MS. The

[Breeding of new Curcuma wenyujin variety "Wenyujin No. 1"].

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In order to breed and spread a new cultivar of Curcuma wenyujin, the C. wenyujin germplasm resources were investigated in authentic regions. Better varieties were chosen by comparing the yield, economic characters and quality differences between different cultivars. The results showed that the

[Analysis of compositions of the essential oil from Curcuma aromatica by gas chromatography-mass spectrometry].

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OBJECTIVE To analyze the compositions of the essential oil from the rhizome of Curcuma aromatica in Guangxi. METHODS The essential oil from the rhizome of Curcuma aromatica was extrated by steam distillation and analysed by GC-MS. RESULTS 50 chemical constituents accounting for 93.11% of total

[Sesquiterpenes from stems and leaves of Curcuma wenyujin].

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OBJECTIVE To study the chemical constituents of the stem and leaves from Curcuma wenyujin. METHODS The compounds were isolated by silica gel column chromatography in associating with Sephadex LH -20 chromatography. While their structures were identified on the basis of spectroscopic

Essential oil constituents from Japanese and Indian Curcuma aromatica rhizomes.

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The chemical compositions of the essential oils from rhizomes of Curcuma aromatica cultivated in Japan and India were analyzed by GC and GC/MS. These oils were extremely different. The major constituents in both oils from Japanese samples were curdione, germacrone, 1,8-cineole,

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