Participants in this arm will be pregnant women with severe hypertension who will receive nifedipine

Participants in this arm will be pregnant women with severe hypertension who will receive hydralazine

Hypertension

Participants in this group will receive 10mg of hydralazine intravenously. This will be repeated every 30 minutes if the blood pressure is equal to or more than 160/110 mmHg after the last dose, up to maximum of five doses.

Hydralazine

Participants in this arm will receive 20mg of nifedipine and the blood pressure will be measured 30 minutes after the dose. This will be repeated every 30 minutes if the blood pressure is equal to or more than 160/110 mmHg after the last dose, up to maximum of five doses

Nifedipine

Alex Ekwueme Federal University Teaching Hospital

Efficacy of Nifedipine Versus Hydralazine in Management of Severe Hypertension in Pregnancy

Efficacy of Nifedipine Versus Hydralazine in Management of Severe Hypertension in Pregnancy - A Randomised Controlled Trial

Number of doses of the drug needed to achieve targeted blood pressure

Number of patients with maternal side effects of the drugs such as: hypotension, nausea, vomiting, dizziness, headache, flushing.

Number of fetuses that develop fetal heart rate abnormality during administration of the drug

Number of live birth and stillbirth among the patients in the study

Mean birth weight of the babies of the patients in the study

APGAR score of less than 7 and 7 and above

Number of children admitted into Neonatal Intensive Care unit

Number of patients who require additional anti-hypertensive drug for control of severe hypertension

The individual will be made available by the corresponding author on request after publication of the manuscript

Adebayo Joshua Adeniyi

Doctor, Senior Registrar, Department of Obstetrics and Gynaecology, Principal Investigator

The participants in the study will be randomized into two study groups in ratio 1:1. One of the study groups will receive 20mg of oral nifedipine while the other arm will receive 10mg of intravenous hydralazine. Each dose is to be repeated after 30 minutes if the blood pressure is equal to or greater than 160/110 mmHg.

serum androgen levels will be measured in 25 normotensive pregnant women

serum androgen levels will be measured in 25 mild preeclamptic patients

serum androgen levels will be measured in 25 severe preeclamptic patients

Severe Preeclampsia

measurement of serum free and total testosterone

serum androgen levels

Ain Shams University

AinShams University

Serum Androgen Levels as a Marker for the Severity of Preeclampsia

assess if serum androgen levels could be used as a marker for the severity of preclampsia

hypertensive encephalopathy/obezite

Efficacy of Nifedipine Versus Hydralazine in Management of Severe Hypertension in Pregnancy

Serum Androgen Levels as a Marker for the Severity of Preeclampsia

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