isobutyric acid/atrofi

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Cytopathogenic effects of atoxyl, an ototoxic compound, on human diploid fibroblasts in vitro.

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Atoxyl, an arsenic compound, may cause degeneration in vivo of the inner ear including cells of the stria vascularis and hair cells. The mechanism behind the cytotoxic effect is not known. The effects of atoxyl at the subcellular level were investigated in this study using human diploid embryonic

Possibility of preventing colorectal carcinogenesis with probiotics.

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OBJECTIVE There have been no reports on the relationship between the analyses of the intestinal flora of colorectal cancer patients and colorectal carcinogenesis. In this study we investigated the differences between the intestinal flora of colorectal cancer patients and healthy subjects and

The effects of cryopreservation on membrane integrity, membrane transport, and protein synthesis in rat hepatocytes.

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The cryopreservation of hepatocytes is of particular interest as a step in the possible treatment of some inborn disorders of metabolism. This study examines the metabolic damage that occurs as a result of the freeze-thaw procedures and during subsequent incubation periods of isolated rat

Olfactory mucosa/air partitioning of odorants.

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The present study evaluates the contribution of the receptor cell compartment to the total mucosal odorant uptake. Using radioactive odorants, partition coefficients for normal bullfrog olfactory mucosa were compared to the partition coefficients from mucosa in which the receptor cells had been

Equilibrium in the Catalytic Condensation of Carboxylic Acids with Methyl Ketones to 1,3-Diketones and the Origin of the Reketonization Effect.

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Acetone is the expected ketone product of an acetic acid decarboxylative ketonization reaction with metal oxide catalysts used in the industrial production of ketones and for biofuel upgrade. Decarboxylative cross-ketonization of a mixture of acetic and isobutyric acids yields highly valued

Hydrogen bond geometries and proton tautomerism of homoconjugated anions of carboxylic acids studied via H/D isotope effects on 13C NMR chemical shifts.

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Ten formally symmetric anionic OHO hydrogen bonded complexes, modeling Asp/Glu amino acid side chain interactions in nonaqueous environment (CDF(3)/CDF(2)Cl solution, 200-110 K) have been studied by (1)H, (2)H, and (13)C NMR spectroscopy, i.e. intermolecularly H-bonded homoconjugated anions of

Starvation induces differential small bowel luminal amino acid transport.

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BACKGROUND The importance of small intestinal mucosa functions has been emphasized in recent years because gut metabolism becomes better defined. One of the major activities of the enterocyte is amino acid transport, which is important not only for the organism but also for the integrity of the

Effect of melatonin on the retinal glutamate/glutamine cycle in the golden hamster retina.

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Glutamate is the main excitatory neurotransmitter in the retina, but it is neurotoxic when present in excessive amounts. The metabolic dependence of glutamatergic neurons upon glia via the glutamate/glutamine cycle to provide the precursor for neurotransmitter glutamate is well established. Since

Characterization of membrane permeability alterations induced in Vero cells by Clostridium perfringens enterotoxin.

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Alterations in plasma membrane permeability induced by Clostridium perfringens enterotoxin were studied using Vero (African green monkey kidney) cells which were radioactively labeled with four markers of different molecular size. The markers were alpha-amino[14C]isobutyric acid (Mr 103), 3H-labeled

Syndromic progressive neurodegenerative disease of infancy caused by novel variants in HIBCH: Report of two cases in Colombia.

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3-Hydroxyisobutyryl-coenzyme A (CoA) hydrolase deficiency (HIBCHD; MIM: #250620) is a rare autosomal recessive inborn error of metabolism caused by a defect in the HIBCH enzyme, resulting in a deficiency of the conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyric acid, a critical step in

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