lambda carrageenan/nekroz

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Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model.

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Sclareol (1) is a natural fragrance compound used widely in the cosmetic and food industries. Lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and the λ-carrageenan-induced edema mouse paw model were applied to examine the anti-inflammatory potential of 1 and its possible molecular

Degraded λ-carrageenan activates NF-κB and AP-1 pathways in macrophages and enhances LPS-induced TNF-α secretion through AP-1.

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BACKGROUND Carrageenan (CGN), a high molecular weight sulfated polysaccharide, is a traditional ingredient used in food industry. Its degraded forms have been identified as potential carcinogens, although the mechanism remains unclear. METHODS The effects of degraded λ-carrageenan (λ-dCGN) on murine

A histopathological study of the effects of intravenously administered lambda carrageenan in the mouse, with particular reference to the macrophage system.

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Intravenously administered lambda-carrageenan rapidly precipitates in the marginal zone of the spleen, the hepatic sinuses and the capillaries of the heart, lung, kidney and adrenal gland. Extensive coagulative necrosis of the liver and myocardium is seen at 24 h. Phagocytosis occurs at 3 days, and

Effect of low molecular lambda-carrageenan from Chondrus ocellatus on antitumor H-22 activity of 5-Fu.

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Lambda-carrageenan is a kind of sulfated galactan isolated from some red algae and reported to have more biological activities than other types, such as K-type [Güven KC, özsoy Y, Ulutin ON. Anticoagulant, fibrinolytic and antiaggregant activity of carrageenans and alginic acid. Bot Mar 1991; 34:

Analgesic and Anti-Inflammatory Activities of Rosa taiwanensis Nakai in Mice.

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In this study, we evaluated the analgesic and anti-inflammatory activities of a 70% ethanol extract from Rosa taiwanensis Nakai (RTEtOH). The analgesic effect was determined using acetic acid-induced writhing response and formalin test. The anti-inflammatory activity was evaluated by

Anti-inflammatory effects of Scoparia dulcis L. and betulinic acid.

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The aims of this study intended to investigate the anti-inflammatory activity of the 70% ethanol extract from Scoparia dulcis (SDE) and betulinic acid on λ-carrageenan-induced paw edema in mice. The anti-inflammatory mechanism of SDE and betulinic acid was examined by detecting the levels of

A novel zebrafish model to provide mechanistic insights into the inflammatory events in carrageenan-induced abdominal edema.

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A suitable small animal model may help in the screening and evaluation of new drugs, especially those from natural products, which can be administered at lower dosages, fulfilling an urgent worldwide need. In this study, we explore whether zebrafish could be a model organism for carrageenan-induced

Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo.

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Inotilone was isolated from Phellinus linteus. The anti-inflammatory effects of inotilone were studied by using lipopolysaccharide (LPS)-stimulated mouse macrophage RAW264.7 cells and λ-carrageenan (Carr)-induced hind mouse paw edema model. Inotilone was tested for its ability to reduce nitric oxide

p-Hydroxyacetophenone suppresses nuclear factor-κB-related inflammation in nociceptive and inflammatory animal models.

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p-Hydroxyacetophenone (HAP) is a crucial chemical compound present in plants of the genus Artemisia, which are used in traditional therapies for treating jaundice, hepatitis, and inflammatory diseases. Nevertheless, the bioactivity of HAP remains to be identified in order to prove its importance in

Carrageenan induces anomalies in the chick embryo. A light microscopic study.

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Chick embryos injected with lambda-carrageenan prior to incubation and studied with light microscopy at 48 hours of development presented various anomalies. Lack of closure at different levels of the neural tube was one of the lesions most frequently seen. Rachischisis and craniorachischisis were

Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress

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Background: Many injuries cause pain and inflammation, which are one of the major challenges for physicians. In this study, the analgesic and the anti-inflammatory effects of milnacipran were investigated on carrageenan-induced

Reticuloendothelial system blockade promotes progression from mild to severe acute pancreatitis in the opossum.

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OBJECTIVE To examine the relation between hepatic reticuloendothelial system (RES) dysfunction and the development of acute biliary pancreatitis. In an opossum model, the authors tested the hypothesis that RES blockade can turn the mild pancreatitis seen after pancreatic duct obstruction (PDO) into

Antioxidant, antinociceptive, and anti-inflammatory activities of Xanthii Fructus extract.

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BACKGROUND Xanthii seeds commonly called Cang-Erzi were used as a traditional Chinese medicine for treating sinusitis, headache due to rheumatism and skin pruritus. OBJECTIVE In order to evaluate the actions of this plant, studies were performed on antioxidant, antinociceptive, and anti-inflammatory

Association of Activation of Induced COX-2, iNOS and Cytokines with NF-kappa B Depression by Taiwan Wild Grape Ethanolic Extract in Mice.

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Taiwan wild grape (Vitis thunbergii var. taiwaniana; VTT) is an important traditional herbal medicine used to treat muscle injuries and acute and chronic pain of the ligaments. Information on its bioactivity and the underlying mechanisms, which have not been elucidated thus far, is needed to

Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation.

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OBJECTIVE We used an experimental model of inflammation in mice, carrageenan-induced paw edema, to study the antiinflammatory effects of the NEMO-binding domain (NBD) peptide, which blocks activation of the inducible transcription factor NF-kappaB. METHODS Paw edema was induced by subplantar

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