The present invention relates to mannose derivatives of formula (I): ##STR00001## wherein R.sub.1 represents H, CO--(C.sub.1-C.sub.6)-alkyl or CO-alkylaryl, Y represents a single bond, CH.sub.2, O, NR.sub.3, S, A represents O, NH or S, X represents H and X' represents OH or X and X' taken together with the carbon atom bearing them form a CO group, R.sub.2 represents H, a linear or branched (C.sub.1-C.sub.6)-alkyl or CF.sub.3, R.sub.3 represents H, a C.sub.1-C.sub.6 alkyl, a CO--(C.sub.1-C.sub.6)-alkyl, CF.sub.3 or COCF.sub.3, and R is as described in claim 1. The mannose derivatives of formulae (I) are useful for treating pathologies associated with the presence of adherent Escherichia coli (AEC), in particular inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis; a urinary tract infection, in particular painful bladder syndrome and cystitis, more particularly interstitial cystitis; irritable bowel syndrome; metabolic diseases such as metabolic obesity, diabetes, hypercholesterolemia; autoimmune inflammatory diseases; and colorectal cancer, in particular colon cancer.

ENTEROME

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

UNIVERSITE CLERMONT AUVERGNE

UNIVERSITE DE NANTES

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Mannose derivatives useful for treating pathologies associated with adherent E. coli

The invention relates to a combination of heat-treated nutritional composition having a carbohydrate fraction comprising a) 5-30 wt % of one or more monosaccharides selected from galactose, ribose and mannose; b) carbohydrates capable of providing b1) sustained release glucose and b2) rapidly available glucose; c) optionally fructose; d) glucose-containing disaccharides other than maltose and sucrose; and e) optionally sugar polyols. The invention also pertains to the use of such a heat-treated nutritional composition for controlling glucose levels in blood and/or tissue, especially for preventing and/or treating diabetics, insulin-resistance, obesity, postprandial glucose response, metabolic syndrome, syndrome X, hyperglycemia, hypertriglyceridemia, hyperinsulinemia, dyslipidemia, dysfibrinolysis and/or disorders associated with major surgery or trauma.

mannose/obezite

Mannose derivatives useful for treating pathologies associated with adherent E. coli

Carbohydrate fraction and use thereof for a flat postprandial glucose response

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