pogostone/pogostemon cablin

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T cell inhibition by pogostone from Pogostemon cablin (Blanco) Benth: In vitro and in vivo immunosuppressive analysis.

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Various plant-derived compounds exhibit immunosuppressive activity in pre‑clinical investigations, suggesting that they may serve as natural alternatives for the prevention of inflammatory disorders and autoimmune diseases. The aim of the current study was to explore the immunosuppressive potential

Aging and/or tissue-specific regulation of patchoulol and pogostone in two Pogostemon cablin (Blanco) Benth. cultivars.

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In Pogostemon cablin (Blanco) Benth. essential oil, patchoulol and pogostone are the two major bioactive phytochemicals while their in vivo biosynthesis remains largely unknown. In this study, seven genes of the plastidic methylerythritol 4-phosphate pathway (MEP) and three genes of the cytoplasmic

In vitro and in vivo antibacterial activity of Pogostone.

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BACKGROUND Our pervious antibacterial studies on several traditional Chinese medicines have found that Patchouli oil from Pogostemon cablin had significant antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), which has spread worldwide and infected innumerable people.

Pogostone suppresses proinflammatory mediator production and protects against endotoxic shock in mice.

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BACKGROUND Pogostemon cablin (Blanco) Benth is a well-known medicinal herb commonly used in many Asian countries for inflammatory diseases. Pogostone (PO), a natural product isolated from Pogostemon cablin, is known to exert various pharmacological activities. This study aimed to investigate the

[Chemical constituents of Pogostemon cablin (Blanco) Benth].

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Nine compounds were isolated from the herb of Pogostemon cablin. They were identified as patchouli alcohol (1), pogostone (2), friedelin (3), epifriedelinol (4), pachypodol (5), retusine (6), oleanolic acid (7), beta-sitosterol (8) and daucosterol (9) on the basis of spectral data (1H-NMR, IR, MS

[Constituents analysis on volatile oil of Pogostemon cablin from different collection time cultivated in Hainan].

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The constituents of the volatile oil of Pogostemon cablin collected from Wanning city, Hainan province and the influence owing to different collection time were undertaken by GC/MS combination technology. The results showed that main compounds was patchouli alcohol in stem oil and leaf oil, its

Quantitative and fingerprinting analysis of Pogostemon cablin based on GC-FID combined with chemometrics.

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In this study, a simple, sensitive and reliable gas chromatography-flame ionization detection (GC-FID) method is established for quantitative chemical fingerprinting of essential oils from Pogostemon cablin. Oil samples are prepared by hydrodistillation, with yields ranging from 0.73% to 2.02%. The

Identification of two chemotypes of Pogostemon cablin (Blanco) Benth. through DNA barcodes.

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Pogostemon cablin (Blanco) Benth. is an important medicinal plant in Traditional Chinese Medicine (TCM). Because of differences in the chemical composition, this species has been classified into two major chemotypes, i. e. the patchouliol-type and the pogostone-type; however, no quick and effective

Evaluation of Contact Toxicity and Repellency of the Essential Oil of Pogostemon cablin Leaves and Its Constituents Against Blattella germanica (Blattodae: Blattelidae).

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The aim of this research was to evaluate contact toxicity and repellency of the essential oil of Pogostemon cablin (Blanco) Bentham leaves against German cockroaches (Blattella germanica) (L.) and to isolate any active constituents. Essential oil of P. cablin leaves was obtained by hydrodistillation

Insecticidal activity of pogostone against Spodoptera litura and Spodoptera exigua (Lepidoptera: Noctuidae).

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BACKGROUND Essential oil of Pogostemon cablin (Blanco) Benth. has been reported to exhibit strong insecticidal activities, but few studies have focused on the insecticidal activity of its main individual constituent, pogostone (PO). The goal of this research was to investigate the insecticidal

[Identification method with significant specificity of volatile oil of Pogostemon cablin].

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OBJECTIVE To develop an identification method with significant specificity for patchouli oil. METHODS The fingerprint was performed by gas chromatography with patchouli alcohol and pogostone as chemical markers. RESULTS The similarity of 12 samples were higher than 0.9 and it can be used to identify

Acaricidal activity of DHEMH, derived from patchouli oil, against house dust mite, Dermatophagoides farinae.

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This study characterized the acaricidal activity of constituents of patchouli oil extracted from (Pogostemon cablin (Blanco) BENTH) against the house dust mite, Dermatophagoides farinae. A new compound, 2-(1,3-dihydroxy-but-2-enylidene)-6-methyl-3-oxo-heptanoic acid (DHEMH), was isolated from

GC-MS fingerprint of Pogostemon cablin in China.

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Pogostemon cablin, originating in Malaysia and India, is cultivated in southern China including Guangdong and Hainan Province, which was called GuangHuoXiang to differentiate it from the HuoXiang of the north, the species Agastache rugosa, that it resembles. Essential oil of P. cablin mainly

Synthesis of pogostone by one-step.

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Pogostone, isolated from Pogostemon cablin, has many biological activities such as potential antibacterial, anticandida, and antifungal. Traditional extraction leads to low output of PO about 17.6 mg/kg from Herba Pogostemonis. The previous literature had reported a synthetic study and the yield had

Synthesis and antimicrobial evaluation of pogostone and its analogues.

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Pogostone (PO) is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity. In this study, PO and a series of its analogues were synthesized by the reaction of dehydroacetate and aldehydes in tetrahydrofuran

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