Light-protection of TPN solutions. TPN bags and infusion sets will be protected from light by aluminum foils throughout the study period.

TPN bags and infusion sets will be exposed to light throughout the study period.

Oxidative Stress in Preterm Infants

TPN bags and infusion sets in the Light-protected group will be covered by aluminum foils to protect the inside TPN solution from exposure to ambient or photo-therapy lights in the NICU. Protection will be made throughout the study period until the infant reaches full feeding and TPN is discontinued.

Light-protection of TPN solutions

Mansoura University Children Hospital

Light Protection of TPN and Oxidative Stress in Preterm Infants

Impact of Protecting TPN Solution From Light on the Oxidant-antioxidant State of Preterm Infant

Measurement of urinary peroxides and serum GSH/GSSG ratio

Death before hospital discharge and/or development of Bronchopulmonary dysplasia defined as oxygen requirement more than 30% fraction of inspired oxygen (FIO2) by 36 weeks corrected gestational age

Necrotizing enterocolitis defined by the modified by Bell's staging criteria

clinical signs of sepsis confirmed by positive blood culture

Pre-threshold and threshold stages of retinopathy of prematurity will be assessed as per our NICU routine by ophthalmology specialist.

Time required to reach full enteral feeding and discontinue TPN

Duration of mechanical ventilation, non-invasive ventilation, and oxygen therapy

Defined as an elevated serum conjugated bilirubin >2 mg/dL (34.2 micromoles/ l)

Episodes of hypoglycemia less than 60 mmol/L, metabolic acidosis with pH less than 7.25 and base deficit more than 10 milliequivalent/L

Duration of admission to the neonatal care unit.

Nehad Nasef

Assistant professor, PhD

Subjects that do not receive cysteine but an isonitrogenous placebo

Sepsis

Bronchopulmonary Dysplasia

Necrotizing Enterocolitis

Retinopathy of Prematurity

Systemic Inflammatory Response Syndrome

cysteine-HCl supplementation 121 mg per kg per day

retinopathy of prematurity/glutathione

Light Protection of TPN and Oxidative Stress in Preterm Infants

Cysteine Supplementation in Critically Ill Neonates

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