sea/skopolamin

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Transdermal scopolamine in the prevention of motion sickness at sea.

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Studies were conducted to evaluate the efficacy of scopolamine, absorbed through intact skin, in preventing motion sickness at sea. Efficacy of transdermal scopolamine was compared with oral dimenhydrinate and placebo. Transdermal applications were made 4 to 16 hr before exposure to motion.

Effects of transdermal scopolamine upon psychological test performance at sea.

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The effects of transdermal scopolamine upon objective psychological performance assessments and self reports of feeling states, were investigated with volunteer subjects at sea. Scopolamine and placebo patches were administered on consecutive days in a counterbalanced order. Psychological

Efficacy of transdermal scopolamine against seasickness: a 3-day study at sea.

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Transdermal scopolamine has been reported to provide protection against motion sickness, both while sailing at sea (7-8 h) and under experimental conditions. In this study, we tested the efficacy of transdermal scopolamine and evaluated its side effects during a 72-h cruise at sea. We tested 38 male

Management of Sea Sickness in Susceptible Flight Crews.

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Sea sickness may greatly impact the readiness of Service personnel deployed aboard naval vessels. Medications used in the treatment of sea sickness may have adverse effects, limiting their use as flight crew. Although the prevalence of sea sickness in flight crews remains unclear, individual

[Motion sickness at sea and in the air].

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Sea sickness was first described in 1881, and since then the syndrome has been described to be associated with travelling also in other means of transportation. Symptoms of motion sickness are quite common in otherwise healthy people. The symptoms are usually of short duration and last for not

Transdermal therapeutic system scopolamine (TTSS), dimenhydrinate, and placebo--a comparative study at sea.

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The efficacy of transdermally administered scopolamine was compared with the efficacy of oral dimenhydrinate and placebo therapy in the prevention of motion sickness at sea. Medication was administered on a controlled double blind basis to 140 subjects. A placebo effect reduced the motion sickness

Influence of transdermal scopolamine on motion sickness during 7 days' exposure to heavy seas.

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We conducted a double-blind, placebo-controlled study to evaluate the efficacy and tolerability of transdermal scopolamine in the prevention of motion sickness (MS) aboard a frigate during 7 days of continuously moderate or heavy seas. Forty-nine healthy sailors with a previous history of MS were

[Transdermal therapeutic system of scopolamine (TTS-S) in the prevention of sea sickness and its mechanism of action].

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The efficacy of transdermal therapeutic system of scopolamine (TTS-S) in the prevention of sea sickness and the extent of its side effects were evaluated in 130 male healthy sailors (volunteers) in a placebo-controlled, double-blind, randomized study. TTS-S or transdermal placebo (TD-P) were placed

Role of cholinergic mechanisms in alterations of rabbit brain functional activity during sea-sickness.

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Using the hydrogen-clearance method in chronic experiments on alert rabbits, we investigated the dynamics of changes in local and total cerebral blood-flow, oxygen pressure, bioelectrical activity of the motor, auditory, and visual zones of the cerebral cortex, the heart rate during sea-sickness and

The Republic of Singapore Navy's Scopoderm TTS study: results after 2,200 man-days at sea.

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Most clinical trials investigating prevention of seasickness with transdermal scopolamine have been short-term, and little information regarding long-term use is available. We report here a double-blind trial conducted on board a flat-bottomed Republic of Singapore Navy vessel of 2,490 tons, sailing

Three-years' experience of transdermal scopolamine: long-term effectiveness and side-effects.

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A study was carried out in 68 otherwise healthy male naval crew members to assess the long-term effectiveness and side-effects of routine transdermal scopolamine administration for the prevention of seasickness. The transdermal patches were applied to the mastoid process before each sailing and the

Scopolamine patch to prevent seasickness: clinical response vs. plasma concentration in sailors.

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BACKGROUND Scopolamine is highly effective for the treatment of seasickness. Nevertheless, transdermal therapeutic system (TTS) scopolamine, despite high compliance on the part of persons treated by the drug, fails to provide protection against seasickness in 26-38% of patients. To the best of our

Side effects of transdermal scopolamine.

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Motion sickness can be experienced as the result of air or sea travel. Scopolamine can be used before travel to prevent this illness. This report describes two patients who used transdermal scopolamine preparations and experienced hallucinations and then confusion as side effects. The discussion

Drug treatment of motion sickness: scopolamine alone and combined with ephedrine in real and simulated situations.

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In two placebo-controlled, double-blind, randomized trials scopolamine (0.3 mg) alone or combined with ephedrine (25 mg) was tested for its effectiveness in the prevention of seasickness during 24 h at sea and of motion sickness in rotating chair tests in a laboratory. Scopolamine was effective both

A comparison of the efficacy of cinnarizine with scopolamine in the treatment of seasickness.

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Scopolamine was compared with cinnarizine in a double-blind sea trial involving 179 subjects from the crews of 2 warships. Medication was initiated prophylactically when weather information indicated the approach of nauseogenic conditions. Ship motion was measured during drug treatment periods. In

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