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Congenital smooth muscle hamartoma of the skin.

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A 2-month-old white girl had a congenital, tan-colored, slightly elevated, 3 x 2-cm plaque on the left midback. Clinically, the lesion was suspected to be a solitary mastocytoma. Rubbing the lesion produced a transient erythema and edema that was similar to Darier sign seen in mastocytoma. Analysis

Intraplacental smooth muscle tumor. A case report.

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BACKGROUND Chorioangioma is the leading diagnosis for circumscribed placental lesion noted on ultrasound. Other rare intraplacental tumors may have a significant clinical impact on the mother and fetus. METHODS An intraplacental, hypoechoic area consistent with chorioangioma was noted on ultrasound

Primary smooth muscle tumors of venous origin.

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Vein tumors are rare, difficult to diagnose, and usually malignant. We have encountered three: a leiomyoma of the jugular vein and leiomyosarcomas of the saphenous vein and inferior vena cava (IVC). The leiomyoma was lost to follow-up, the saphenous vein leiomyosarcoma survived nine years, and the

Effect of lung inflation in vivo on airways with smooth muscle tone or edema.

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Fibrous attachments to the airway wall and a subpleural surrounding pressure can create an external load against which airway smooth muscle must contract. A decrease in this load has been proposed as a possible cause of increased airway narrowing in asthmatic individuals. To study the interaction

Acquired smooth-muscle hamartoma of the scrotum: a histological simulator?

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BACKGROUND In three cases of chronic scrotal lymphedema, histological and immunohistochemical changes were observed that were strikingly similar to an exceedingly rare lesion reported previously under the name of acquired smooth-muscle hamartoma (ASMH) of the scrotum. The clinical context indicated

A comprehensive mathematical framework for modeling intestinal smooth muscle cell contraction with applications to intestinal edema.

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The contraction of intestinal smooth muscle cells (ISMCs) involves many coordinated biochemical and mechanical processes. In this work, we present a framework for modeling ISMC contractility that begins with chemical models of calcium dynamics, continues with myosin light chain phosphorylation and

Lymphatic smooth muscle responses to leukotrienes, histamine and platelet activating factor.

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Regional lymphatics regulate the accumulation of edema resulting from inflammation. The effects of mediators of inflammation on lymphatic smooth muscle, the primary determinant of lymph flow, are poorly understood. We studied mesenteric lymphatic vessels in 22 anesthetized rats with in vivo

Pulmonary vascular smooth muscle function in porcine splanchnic arterial occlusion shock.

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Pulmonary complications are a major cause of death in patients in various forms of shock. The exact causes of the pulmonary complications are unknown. This study evaluates the functional characteristics of intralobar pulmonary arteries (IPA) and veins (IPV) obtained from swine subjected to

Inhibition of smooth muscle myosin as a novel therapeutic target for hypertension.

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We examined a novel therapeutic approach for hypertension, a small-molecule direct inhibitor of smooth muscle myosin, CK-2018448 (CK-448), which is an N,N'-alkylurea (U.S. Patent Publication 2009-0275537 A1) in conscious dogs with renal hypertension and compared its efficacy with that of a calcium

A novel homozygous splice-site mutation in RYR1 causes fetal hydrops and affects skeletal and smooth muscle development.

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The Effect of Schinus terebinthifolius Raddi (Anacardiaceae) Bark Extract on Histamine-Induced Paw Edema and Ileum Smooth Muscle Contraction.

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Schinus terebinthifolius Raddi (Anacardiaceae), popularly known as red aroeira, is used in traditional medicine to treat inflammatory, gastric, and respiratory disorders. The aim of this study was to evaluate the antihistaminic activity of S. terebinthifolius (St) bark extract by using in vivo and

Selective pulmonary and venous smooth muscle relaxation by furosemide: a comparison with morphine.

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Furosemide and morphine reduce pulmonary edema associated with congestive heart failure. It is uncertain whether furosemide or morphine are direct-acting relaxants of arterial and venous smooth muscle. The authors compared the effect of furosemide and morphine on isolated rings of canine pulmonary

The response of smooth muscle cells in the rabbit urinary bladder to outflow obstruction.

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The morphologic response of smooth muscle cells in the urinary bladder to a standardized bladder neck obstruction and the cell changes subsequent to release of that obstruction were studied in both growing and adult rabbits. The bladder reacted first by gross dilation and then by concentric

A model of the mechanics of smooth muscle reservoirs applied to the intestinal bladder.

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A model of the mechanics of smooth muscle reservoirs was derived from the stress-strain relation in smooth muscle strips. The model was applied to the intestinal bladder reservoir but may also be applied to natural reservoirs such as the bladder. The relation between reservoir volume and pressure

Use of the smooth Teflon clip to prevent pulmonary embolism in the postoperative period.

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This report details experience with 50 patients who had vena caval interruption with a smooth Teflon (Moretz) clip placed at the time of surgery for other conditions in a high-risk patient population. No fatal pulmonary emboli were encountered; one patient developed bilateral iliofemoral venous

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