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Nucleophilic Addition of Thiols to Deoxynivalenol.

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Conjugation of deoxynivalenol (DON) with sulfur compounds is recognized as a significant reaction pathway, and putative DON-glutathione (DON-GSH) conjugates have been reported in planta. To understand and control the reaction of trichothecenes with biologically important thiols, we studied the

Polymer: bioceramic composites optimization by tetracycline addition.

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The aim of this study was to evaluate the biocompatibility of composites of poly-lactic acid polymer (PLA) and copolymer of lactic and glycolic acid (PLGA), dispersed in a bioceramic matrix, Osteosynt (BC), to which tetracycline (TC) was added. The in vitro test used direct contact test (ASTM F-813)

Interferons. New additions and indications for use.

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Within the past few years, natural and recombinant cytokines have become available for clinical use. The broadest clinical experience exists with the interferons because these were available first. This article discusses the clinical efficiency and therapeutic value of natural and recombinant

[Endoscopic ultrasonography--an addition to pancreas diagnosis?].

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Endoscopic ultrasonography (EUS) has been developed for high resolution imaging of the upper gastrointestinal tract and immediate surroundings, such as the pancreas and the biliary tract. The ultrasonic transducer at the tip of the instrument works with ultrasound frequencies of 7.5 MHz and provides

Statins: novel additions to the dermatologic arsenal?

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The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins), atorvastatin, cerivastatin, fluvastatin, pravastatin, lovastatin and simvastatin, reduce atherogenesis and cardiovascular morbidity. Besides, there is growing evidence that statins have immunomodulatory activities.

Inflammatory response during simulated extracorporeal circulation with addition of nitric oxide.

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BACKGROUND Heart operations performed with extracorporeal circulation (ECC) are associated with an inflammatory response. This response is partially due to granulocyte activation. Leukocyte derived free radicals are involved in tissue injury. The purpose of this study was to observe whether nitric

Cardiovascular Risk Management Targeting Inflammation in Addition to Lipid-lowering Therapy.

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Testosterone addition to estrogen therapy - effects on inflammatory markers for cardiovascular disease.

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OBJECTIVE To analyze the effects of testosterone addition to estrogen therapy in comparison with estrogen alone on cardiovascular risk factors in postmenopausal women. METHODS Fifty surgically postmenopausal women were included in this double-blind, placebo-controlled and randomized study to receive

Alterations of intraperitoneal inflammation by the addition of L-2-oxothiazolidine-carboxylate.

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The authors studied the effect of L-2-oxothiazolidine-carboxylate (OTZ), a substrate for intracellular glutathione synthesis, in an in vivo model of lipopolysaccharide (LPS)-induced peritonitis in rats. The addition of LPS to dialysis fluid increased the white blood cell (WBC) count and the nitrite

Effect of the addition of montelukast to inhaled fluticasone propionate on airway inflammation.

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The aim of the study was to investigate the effect of addition of montelukast to inhaled fluticasone propionate (FP) therapy, compared with FP therapy alone (100 microg twice a day) on airway immunopathology in individuals with mild asthma. Twenty-eight subjects received FP (100 microg twice a day)

The latest addition to the inflammatory homeboys in chronic kidney disease: interleukin-8.

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Nicotinamide: a potential addition to the anti-psoriatic weaponry.

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Psoriasis is an inflammatory disorder characterized by a T helper type 1 cell cytokine pattern. Increased expression of adhesion molecules, prominent neutrophil accumulation, and increased production of nitric oxide are characteristics of this disorder. Moreover, histamine and proteases are supposed

Autoinflammation in addition to combined immunodeficiency: SLC29A3 gene defect.

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H Syndrome is an autosomal recessive (AR) disease caused by defects in SLCA29A3 gene. This gene encodes the equilibrative nucleoside transporter, the protein which is highly expressed in spleen, lymph node and bone marrow. Autoinflammation and autoimmunity accompanies H Syndrome

Methylglyoxal, a Reactive Glucose Metabolite, Induces Bladder Overactivity in Addition to Inflammation in Mice.

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Diabetic bladder dysfunction (DBD) is one of the most common complication of diabetes. Methylglyoxal (MGO), a highly reactive dicarbonyl compound formed as a by-product of glycolysis, is found at high levels in plasma of diabetic patients. Here, we explored the effects of chronic administration of

Addition of fexofenadine to inhaled corticosteroid therapy to reduce inflammatory biomarkers in atopic asthma.

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BACKGROUND We previously showed that H1-antihistamines may shift the PC20 (provocation concentration that caused a decrease in forced expiratory volume in 1 second of 20%) threshold to adenosine monophosphate (AMP) challenge but may paradoxically prolong recovery. OBJECTIVE To measure AMP recovery

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Herbal & Natural Medicine

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