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Addition of droperidol to patient-controlled analgesia: effect on nausea and vomiting.

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A double-blind trial of the effect of droperidol on the incidence of nausea and vomiting in patients using patient-controlled analgesia was carried out in 60 healthy women undergoing abdominal hysterectomy. After a standard anaesthetic including droperidol 2.5 mg as a prophylactic antiemetic,

Clonidine addition prolongs the duration of caudal analgesia.

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BACKGROUND In this study, using a dose-ranging design, we examined the effects of clonidine with 0.125% bupivacaine on the duration of post-operative analgesia in caudal anaesthesia in children. METHODS We conducted a controlled, prospective study of clonidine in caudal anaesthesia in 60 children,

Is liraglutide a useful addition to diabetes therapy?

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OBJECTIVE To evaluate liraglutide as an antidiabetic agent. METHODS The pertinent English-language medical literature was reviewed for the period from 1985 to April 2010 with use of data from MEDLINE. RESULTS Liraglutide is a glucagonlike peptide-1 receptor analogue that stimulates insulin

Is exenatide a useful addition to diabetes therapy?

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OBJECTIVE To present an evidence-based evaluation of the antidiabetic drug exenatide. METHODS The English literature from 1965 to January 2006 was reviewed by using data sources from MED-LINE, endocrinology textbooks, and manual searching of cross-references from original articles and

Sequential addition of aprepitant in patients receiving carboplatin-based chemotherapy.

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Chemotherapy-induced nausea and vomiting is a challenging issue. Although aprepitant is sometimes used as a therapeutic option in patients receiving moderately emetogenic chemotherapy, the potential benefit of sequential addition of aprepitant to dexamethasone and a 5-hydroxytryptamine-3 (5-HT3)

Intrathecal addition of morphine to bupivacaine is not the cause of postoperative nausea and vomiting.

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OBJECTIVE Postoperative nausea and vomiting after anesthesia is an distressing side effect. This study was undertaken to determine to what extent spinal opioids contribute to postoperative nausea and vomiting (PONV) and secondly to how effectively metoclopramide can reduce the incidence of PONV

Propofol injection pain: comparing the addition of lignocaine or metoclopramide.

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Lignocaine has been shown to reduce the incidence of pain on injection of propofol. Metoclopramide, a weak local anaesthetic and commonly used antiemetic, was combined with propofol and the mixture compared, in a prospective, randomized trial, with a lignocaine-propofol combination. The incidence of

Addition of aprepitant improves protection against cisplatin-induced emesis when a conventional anti-emetic regimen fails.

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OBJECTIVE We investigated whether aprepitant, a neurokinin-1 antagonist, could decrease chemotherapy-induced nausea and vomiting (CINV) following cisplatin, when a conventional anti-emetic regimen had failed. METHODS This was a prospective study (April 2011-April 2012) of patients with lung cancer,

Efficacy of sufentanil addition to ropivacaine epidural anaesthesia for Caesarean section.

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BACKGROUND This prospective double-blind trial evaluated the effect of sufentanil addition to epidural ropivacaine for elective Caesarean section. METHODS Sixty healthy parturients were randomly assigned to receive an initial dose of 90 mg of plain ropivacaine, or 90 mg of ropivacaine plus 10 or 20

Epidural ropivacaine 1% with and without sufentanil addition for Caesarean section.

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BACKGROUND So far only ropivacaine concentrations of 0.5 and 0.75% have been used for Caesarean section. This prospective double-blind trial evaluated the anaesthetic quality of ropivacaine 1% with and without sufentanil addition. METHODS Three groups of patients (n=20 each) scheduled for an

The addition of dexamethasone to dolasetron or haloperidol for treatment of established postoperative nausea and vomiting.

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It is not known whether dexamethasone increases the effectiveness of anti-emetics when given to treat postoperative nausea and vomiting (PONV). In a randomised study, 242 patients who were experiencing PONV received dolasetron and placebo, haloperidol and placebo, dolasetron and dexamethasone, or

Addition of meperidine to bupivacaine for spinal anaesthesia for Caesarean section.

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BACKGROUND In a prospective, randomized, double-blind, placebo-controlled trial, we investigated the effect of adding meperidine 10 mg to intrathecal bupivacaine on the duration of early postoperative analgesia in 40 patients having elective Caesarean section under spinal

Fidaxomicin: the newest addition to the armamentarium against Clostridium difficile infections.

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BACKGROUND Fidaxomicin, a macrolide antibiotic, was the first medication for the management of Clostridium difficile infections (CDI) to be approved by the US Food and Drug Administration in more than 20 years. OBJECTIVE This article reviews published literature on fidaxomicin for management of CDI,

Improved control of high-dose-cisplatin-induced acute emesis with the addition of prochlorperazine to granisetron/dexamethasone.

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OBJECTIVE To evaluate the antiemetic efficacy and safety of adding the dopamine antagonist prochlorperazine to the combination of granisetron and dexamethasone in the prevention of acute nausea and vomiting following high-dose cisplatin. METHODS Sixty patients receiving cisplatin (> or = 75 mg/m2)

Addition of drug/s to a chemotherapy regimen for metastatic breast cancer.

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BACKGROUND The addition of a chemotherapy drug or drugs to an established regimen is one method used to increase the dose and intensity of treatment for metastatic breast cancer. OBJECTIVE To identify and review the randomised trial evidence in the first line management of women with metastatic
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