Apatinib for Inoperable Advanced Chondrosarcoma

Inclusion Criteria:

- 1) histologically confirmed high-grade sarcoma;

- 2) initial treatment in the orthopedic oncology departments of the two affiliated hospitals of Peking University;

- 3) tumors not amenable to curative treatment or inclusion in clinical trials;

- 4) unresectable local advanced lesions or multiple metastatic lesions that could not be cured by local therapy;

- 5) measurable lesions according to Response Evaluation Criteria for Solid Tumors (RECIST1.1) ;

- 6) Eastern Cooperative Oncology Group performance status 0 or 1;

- 7) acceptable hematologic, hepatic, and renal function.

Exclusion Criteria:

- had central nervous system metastasis;

- had other kinds of malignant tumors at the same time; had cardiac insufficiency or arrhythmia;

- had uncontrolled complications such as diabetes mellitus, coagulation disorders, urine protein ≥ ++ and so on;

- had pleural or peritoneal effusion that needs to be handled by surgical treatment;

- combined with other infections or wounds;

- pregnant or breastfeeding.