Avenanthramide and Saponin Bioavailability in Oat Bran
Ключові слова
Анотація
Опис
Initially, the diet of the participants will be asked to restricted to avoid eating any polyphenols that might interfere with the employed analytical chemistry techniques. This period of diet restriction is the washout period. The list of foods to avoid are: oats, whole grains, fruits, vegetables, herbal supplements, ginger, coffee, tea, and chocolate.
After the washout period, a baseline urine and fecal sample will be collected from the participants, then a large portion of oat bran will be provided to the participants for consumption. The approximate portion size will be 100 g by dry weight. The participants will then provide urine samples during the designated time points. The time points for the urine collection are as follows:
1. st sample, ~ 30 min to 1 hour prior to oat consumption
2. nd sample: 0-2 hours after oat consumption
3. rd sample: 2-4 hours after oat consumption
4. th sample: 4-6 hours after oat consumption
5. th sample: 6-9 hours after oat consumption
6. th sample: 9-12 hours after oat consumption
7. th sample: 12-24 hours after oat consumption
8. th sample: 24-32 hours after oat consumption
9. th sample: 48 hours after oat consumption These samples will be analyzed in using HPLC and LC/MS.
Дати
| Востаннє перевірено: | 03/31/2020 |
| Перший поданий: | 04/01/2020 |
| Орієнтовна реєстрація подана: | 04/02/2020 |
| Опубліковано вперше: | 04/05/2020 |
| Останнє оновлення надіслано: | 04/02/2020 |
| Останнє оновлення опубліковано: | 04/05/2020 |
| Фактична дата початку навчання: | 01/14/2016 |
| Розрахункова дата первинного завершення: | 01/20/2016 |
| Розрахункова дата завершення дослідження: | 01/20/2016 |
Стан або захворювання
Втручання / лікування
Dietary Supplement: Oat Bran Consumption
Фаза
Групи рук
| Рука | Втручання / лікування |
|---|---|
| Experimental: Oat Bran Consumption Each subject consumed 120 g of oat bran (by dry weight) in a single dose, and samples (urine and fecal) were collected at different time points following the administration of oat bran. | Dietary Supplement: Oat Bran Consumption Oat bran (120 g), single dose. |
Критерії прийнятності
| Вік, придатний для навчання | 18 Years До 18 Years |
| Стать, яка підходить для вивчення | All |
| Приймає здорових добровольців | Так |
| Критерії | Inclusion Criteria: - BMI 18.5-25 - Have blood and urine biochemical markers in normal range - Have no known allergy to oat relate foods - Be not taking antibiotics for six months - Be not currently taking medication - Be nonsmoking - Have no alcoholic intoxication - Have no extensive exposure to industrial waste Exclusion Criteria: - Individuals with gout - Individuals with heart disease - Individuals with peripheral vascular diseases - Individuals with degenerative liver - Cancer patients - Patients with diabetes - Individuals with GI disorders - Individuals with endocrine disorders |
Результат
Заходи первинного результату
1. Bioavailability of Avenanthramides and Saponins in Urine [0-2 hours post-dose]
2. Bioavailability of Avenanthramides and Saponins in Urine [2-4 hours post-dose]
3. Bioavailability of Avenanthramides and Saponins in Urine [4-6 hours post-dose]
4. Bioavailability of Avenanthramides and Saponins in Urine [6-9 hours post-dose]
5. Bioavailability of Avenanthramides and Saponins in Urine [9-12 hours post-dose]
6. Bioavailability of Avenanthramides and Saponins in Urine [12-24 hours post-dose]
7. Bioavailability of Avenanthramides and Saponins in Urine [24-32 hours post-dose]
8. Bioavailability of Avenanthramides and Saponins in Urine [32-48 hours post-dose]
