Serum Magnesium Level Administration in Severe Pre-eclampsia Obese Pregnancy
Ключові слова
Анотація
Опис
Magnesium sulfate is, generally, applied in order to alleviate or to avoid seizures. It can be administered according to many medical approaches. Nevertheless, at Rajavithi Hospital, the recommended administration of magnesium sulfate is 4 grams for loading dose in 15 minutes, followed by 2 grams for maintenance dose per hour (Zudpan regimen). The therapeutic index of magnesium is in the range of 4.8-8.4 mg/dL. After that, the level of magnesium sulfate will be evaluated every 4 or 6 hours.
At Rajavithi Hospital, there are a lot of patients having pre-eclampsia symptom and many patients, who were received magnesium sulfate in the treatment, having the level of magnesium sulfate lower than the therapuetic level and needed to increase the maintenance dose to 2.5 grams/hour. Therefore, this work aims to studying the amount of magnesium sulfate administered to pregnant woman with pre-eclampsia symptom who possess high body mass index (BMI), especially for BMI greater than or equal to 30 kg/m2.
Дати
| Востаннє перевірено: | 08/31/2018 |
| Перший поданий: | 05/13/2018 |
| Орієнтовна реєстрація подана: | 09/04/2018 |
| Опубліковано вперше: | 09/06/2018 |
| Останнє оновлення надіслано: | 09/04/2018 |
| Останнє оновлення опубліковано: | 09/06/2018 |
| Фактична дата початку навчання: | 09/29/2018 |
| Розрахункова дата первинного завершення: | 12/29/2018 |
| Розрахункова дата завершення дослідження: | 12/29/2018 |
Стан або захворювання
Втручання / лікування
Drug: Magnesium sulfate administration
Фаза
Групи рук
| Рука | Втручання / лікування |
|---|---|
| Experimental: controlled group controlled group : administration of magnesium sulfate is 4 grams for loading dose in 15 minutes, followed by 2 grams for maintenance dose per hour | |
| Experimental: Experimental group group : administration of magnesium sulfate is 4 grams for loading dose in 15 minutes, followed by 2.5 grams for maintenance dose per hour |
Критерії прийнятності
| Стать, яка підходить для вивчення | Female |
| Приймає здорових добровольців | Так |
| Критерії | Inclusion Criteria: - Pregnancy women who have MBI ≥ 31kg/m2 - Pregnancy women who were diagnosed severe pre-eclampsia at gestational age 24 weeks more. - Pregnancy women who were diagnosed eclampsia at gestational age 24 weeks more. Exclusion Criteria: - Pregnancy women who were chronic kidney disease or have serum creatinine more than 1.1 mg/dl - Pregnancy women who have contraindication to use magnesium sulfate |
Результат
Заходи первинного результату
1. therapeutic level [4 hours after infusion magnesium sulfate]
Заходи вторинного результату
1. Outcome of pregnancy [24 hours after delivery]
