Non-immune hydrops associated with congenital herpes simplex infection.

Non-immune hydrops fetalis is a rare pregnancy complication, which can be caused by a myriad of conditions. Etiologies include metabolic or chromosomal disorders, fetal structural anomalies, and fetal infections. We present a case of non-immune hydrops caused by an intra-uterine infection with Type 1 Herpes Simplex Virus. Evaluation of the fetus with non-immune hydrops should include an amniocentesis for viral culture of the amniotic fluid.