Diabetes

Patients suffering from type 2 diabetes will be randomized to receive 100 mg/day or placebo for one year

Aspirin

Patients in this arm will be treated with placebo

Placebo

Internal and Medical Specialities Department - Policlinico Umberto I

Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes

Effect of Aspirin on Renal Disease Progression in Patients With Type 2 Diabetes: a Multicentre Double-blind, Placebo-controlled, Randomised Trial. The LEDA (renaL disEase Progression by Aspirin in Diabetic pAtients) Study.

The aim of our study is to evaluate the decline in renal function in diabetic patients treated with low-dose aspirin (100 mg/day) vs. untreated diabetic patients. In particular, we will evaluate:
The absolute change in eGFR, calculated as the difference between eGFR at 12 months - baseline eGFR;
The rapid decline in renal function, defined as a reduction of eGFR ≥5 ml/min at 1 years.
The change of renal function class (from G1 to G2, from G2 to G3a and so on) at 6 and 12 months.

As secondary endpoint, we will evaluate changes in the urinary excretion TxB2 both baseline and at one year. Changing levels of urinary TxB2 will then be related to renal function.

Francesco Violi

Full professor

University of Roma La Sapienza

Evaluation of cardiovascular risk factors, oxidative stress and fatty acid metabolism in a cohort of blood donors

Cardiovascular Disease

AVIS

Vascular Medicine Unit, Department of Medical Science and Biotechnology

Cardiovascular Risk Factors, Lipid Metabolism and Oxidative Stress

Relation Between Fatty Acids and Oxidative Stress Markers With Cardiovascular Risk Factors in a Healthy Population

Assessment of plasma reference values of the complete fatty acid profile, oxysterols and alpha- and gamma-tocopherol in healthy italian subjects

The assessment of the complete fatty acids profile, oxysterols and vitamin E (alpha- and gamma-tocopherol) would reveal associations with components cardiovascular risk factors of the metabolic syndrome

Prospective evaluation of cardiovascular events as function of baseline fatty acids and oxidative stress

arachidonate/ожиріння

Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes

Cardiovascular Risk Factors, Lipid Metabolism and Oxidative Stress

Найповніша база даних про лікарські трави, підкріплена наукою