Oral Valgancyclovir 900 mg twice in a day during 4 weeks prior to initiation of cART (combined antirretroviral therapy) until suppression of HHV-8.

Standard treatment with cART according to current HIV Therapy Mexican guidelines.

Kaposi Sarcoma

Human Immunodeficiency Virus

Immune Reconstitution Syndrome

The experimental group will receive Valganciclovir 900 mg twice in a day before the initiation of cART until viral load of HHV-8 is undetectable.

Valganciclovir

Patients will receive standard antiretroviral treatment as recommended

Antiretroviral Combinations

Instituto Nacional de Cancerologia

Valganciclovir Four Weeks Prior to cART Initiation Compared to Standard Therapy for Disseminated Kaposi Sarcoma

Valganciclovir for Suppression of HHV-8 Four Weeks Prior to Initiation of cART in Patients With Disseminated Kaposi Sarcoma Compare With Standard Therapy, Its Impact on the Development of IRIS and Attributable Mortality

Measure mortality attributable to IRIS-KS in all the groups

Volkow Fernandez Patricia Amalia

Infectious disease consultant, Clinical Professor

National Institute of Cancerología

Instituto Nacional de Enfermedades Respiratorias

Patients receiving chemotherapy (anthracycline-based) will be randomized to esomeprazole for Cycle 1 Days 1-5 and Cycle 2 Days 1-5

Subjects will be given placebo Cycle 1 Days 1-5 and Cycle 2 Days 1-5.

Subjects will be given esomeprazole 40mg daily by mouth for Cycle 1 Days 1-5 and Cycle 2 Days 1-5.

Esomeprazole

Subjects will be given placebo(surgar pill) 40mg daily by mouth for Cycle 1 Days 1-5 and Cycle 2 Days 1-5.

Sugar Pill

Total

Age, Customized

Sex: Female, Male

Proportion of patients who exhibit no more than one emetic episode and who do not require rescue medication for nausea from 2-7 days following chemotherapy. Thus, we will look at esomeprazole when used to decrease the incidence,severity and duration of nausea/vomiting/retching in breast cancer patients who are receiving anthracycline-based chemotherapy.

The first dose of esomeprazole 40 mg will be administrated prior to the initiation of chemotherapy along with the standard antiemetics for each cycle. On day 2 to 5 following chemotherapy, the patient will take one capsule each morning.

The frist dose of sugar pill 40 mg will be administrated prior to the initiation of chemotherapy along with the standard antiemetics for each cycle. On day 2 to 5 following chemotherapy, the patient will take one capsule each morning.

Number of Times a Subject Felt Sick to Her Stomach and Number of Times a Subject Required Rescue Medication

Overall Study

Mothaffar Rimawi

The frist dose of esomeprazole 40 mg will be administrated prior to the initiation of chemotherapy along with the standard antiemetics for each cycle. On day 2 to 5 following chemotherapy, the patient will take one capsule each morning.

Nausea

esomeprazole

Placebo 1 pill daily Cycle 1 Days 1-5 and Cycle 2 Days 1-5

cytosine/карієс зубів

Valganciclovir Four Weeks Prior to cART Initiation Compared to Standard Therapy for Disseminated Kaposi Sarcoma

Nexium Study To Suppress Nausea During Chemotherapy

Найповніша база даних про лікарські трави, підкріплена наукою