Сторінка 1 від 23 результати
BACKGROUND OF THE INVENTION
The pathway of uridine monophosphate synthesis has been studied extensively and is reasonably well understood. It has been determined that oritidine monophosphate (OMP) decarboxylase catalyzes the conversion of oritidine monophosphate to uridine monophosphate, in the de
BACKGROUND OF THE INVENTION
Histamine has a pivotal role in a variety of in vivo reactions. Endogenous histamine plays an important role in regulating cell proliferation in normal and neoplastic cells. Increased histamine biosynthesis and content has been reported in different human and experimental
FIELD OF THE INVENTION
The present invention relates to novel compounds, their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme
FIELD OF THE INVENTION
The present invention relates to novel compounds, their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme
FIELD OF THE INVENTION
The present invention relates to novel compounds, their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme
FIELD OF THE INVENTION
The present invention relates to methods of treatment of certain metabolic diseases and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this
FIELD OF THE INVENTION
The present invention relates to methods of treatment of certain metabolic diseases and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this
FIELD OF THE INVENTION
The present invention relates to met hods of treatment of certain metabolic diseases and the use of compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular,
This application has been filed under 35 USC 371 as a National Stage application of PCT/EP 96/00143, filed Jan. 15, 1996.
BRIEF DESCRIPTION OF THE INVENTION
The invention relates to novel imidazole derivatives, to tautomers thereof and/or to salts thereof, to a process for the preparation of those
FIELD OF INVENTION
The present invention relates to the field of cancer. More specifically, the present invention relates to a method and compositions for treating prostate cancer by inhibiting the enzyme dopa decarboxylase (DDC).
BACKGROUND OF THE INVENTION
Prostate cancer may cause pain,
REFERENCE TO A SEQUENCE LISTING SUBMITTED AS A TEXT FILE VIA EFS-WEB
The official copy of the sequence listing is submitted on Jun. 18, 2008 as a text file via EFS-Web, in compliance with the American Standard Code for Information Interchange (ASCII), with a file name of 301942_SequenceListing.txt,
BACKGROUND OF THE INVENTION
Polyamines play important roles in normal and cancer cell growth. Elevated ornithine decarboxylase (ODC) activity is observed in neoplastic tissues suggesting that this enzyme is a target for cancer prevention or treatment. Difluoromethylomithine (DFMO), an approved FDA
BACKGROUND OF THE INVENTION
I. Field of the Invention
The present invention relates generally to the fields of cancer biology and medicine. More particularly, it concerns methods for the diagnosis, prevention, and treatment of carcinomas and risk factors thereof.
II. Description of Related
FIELD OF THE INVENTION
The present invention relates to methods of treatment of certain metabolic diseases and the use of compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, the
FIELD OF THE INVENTION
The present invention relates to methods of treatment of certain metabolic diseases and the use of compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, the