Inflammatory Back Pain

The investigators will evaluate the effect of a gluten free diet (GFD) in IBP patients, randomly assigned to receive standard therapy for IBP or standard therapy for IBP plus GFD, for a period of at least one year.

Gluten free diet

Department of Internal Medicine, Giovanni Paolo II Hospital of Sciacca

Department of Internal Medicine, University Hospital of Palermo

Inflammatory Back Pain and Gluten Free Diet

Musculoskeletal (back pain) evaluation, from baseline at 12 months of GFD, according to the scores calculated on the basis of Visual Analogue Scales for Musculoskeletal (back pain), taking into account whether the patients adhered or not to the GFD.

Changes in cytokines production from peripheral blood mononuclear (PBMC), from baseline (i.e. at diagnosis) at 12 months of GFD, taking into account whether the patients adhered or not to the GFD.

Prevalence of IBP in CD and in NCWS patients.

Pasquale Mansueto

University of Palermo

The Erchonia HP Scanner (HPS) Laser contains 3 independent diodes mounted in scanner devices and positioned equidistant from each other and titled at a 30 degree angle. Each scanner emits 17 milliwatts (mW), 635 nm of red laser light.

The Erchonia HP Scanner (HPS) Laser contains 3 independent diodes mounted in scanner devices and positioned equidistant from each other and titled at a 30 degree angle. Each scanner emits 17 milliwatts (mW), 635 nm of red laser light.
Erchonia HP Scanner (HPS): The Erchonia HP Scanner (HPS) Laser is administered to the subject's heel 6 times across 3 consecutive weeks, 2 times each week, for 10 minutes of treatment time per administration.

Erchonia HP Scanner (HPS)

Sex: Female, Male

Ethnicity (NIH/OMB)

Region of Enrollment

Duration of heel pain is recorded as number of months of chronic heel pain experienced prior to study enrollment

Duration of Heel Pain

The Visual Analog Pain Scale (VAS) is one of the three most commonly used scales for assessing chronic pain consisting of a 100 millimeter (mm) horizontal line anchored at one end by the label "0: no pain at all" and at the other end "100: worst pain imaginable". The subject marks on the line the spot for the overall degree of pain experienced in the study treated heel region upon waking in the morning and taking the first few steps of the day, which is then measured using a ruler.

Degree of Heel Pain on the Visual Analog Scale (VAS)

Skin Perfusion Pressure (SPP) measured peripheral microcirculation or skin perfusion using a laser Doppler sensor and a pressure cuff to evaluate reactive hyperemia, the transient increase in blood flow that occurs following a brief period of ischemia. The SPP value was measured in mmHg.
The per cent (%) change in mean Skin Perfusion Pressure (SPP) in mmHg was calculated as the % change in measurements from before the first procedure administration with the Erchonia® HPS Laser to after the sixth and final procedure administration. It was pre-determined that a minimum mean change in % SPP of +10% or greater across the evaluation period would be considered clinically meaningful.
A positive (+) change indicates that SPP increased across the procedure administration phase and is positive for study efficacy.
A negative (-) change indicates that SPP decreased across the procedure administration phase and is negative for study efficacy.

Change in Skin Perfusion Pressure (SPP)

Skin surface temperature on the hind foot was recorded in degrees using an infrared thermometer. Change in skin surface temperature in degrees was calculated as the change in measurements before the first procedure administration (baseline) to after the sixth and final procedure administration. It was pre-determined that a minimum mean increase in skin surface temperature of +2.5 degrees across the procedure administration phase would be considered clinically meaningful.
A positive (+) change indicates that the skin surface temperature increased across the procedure administration phase and is positive for study efficacy.
A negative (-) change indicates that the skin surface temperature decreased across the procedure administration phase and is negative for study efficacy.

Change in Skin Surface Temperature on the Hind Foot

Overall Study

Kerry Zang, DPM

Defective; Circulation

The Erchonia HP Scanner (HPS) Laser is administered to the subject's heel 6 times across 3 consecutive weeks, 2 times each week, for 10 minutes of treatment time per administration.

fasciitis/головний біль

Inflammatory Back Pain and Gluten Free Diet

Study of Low Level Laser Light Therapy to Improve Blood Circulation in People With Chronic Heel Pain

Найповніша база даних про лікарські трави, підкріплена наукою