Subjects will be tested on one day. Baseline testing will take place and will be followed by oral antioxidant cocktail intake. Oral antioxidant cocktail testing will take place ~2 hours after antioxidant intake.
During baseline testing, no supplement or placebo intake will be used.

Subjects will be tested on one day. Baseline testing will take place and will be followed by oral antioxidant cocktail intake. Oral antioxidant cocktail testing will take place ~2 hours after antioxidant intake.
Dose 1:(immediately after baseline) 300 mg alpha-lipoic acid, 500 mg vitamin C, 200 IU vitamin E Dose 2: (30 minutes after dose 1) 300 mg alpha-lipoic acid, 500 mg vitamin C, 400 IU vitamin E

Cardiovascular Diseases

Oral antioxidant cocktail intake will occur after baseline measurements:
Dose 1 (immediately after baseline testing): 300 mg alpha-lipoic acid, 500 mg vitamin C, 200 IU vitamin E Dose 2 (30 minutes after Dose 1): 300 mg alpha-lipoic acid, 500 mg vitamin C, 400 IU vitamin E

Oral antioxidant cocktail

No oral antioxidant cocktail intake or placebo intake will occur prior to baseline measurements

Baseline

Effects of Oral Antioxidant Cocktail in Cardiovascular Disease Patients

Effects of Oral Antioxidant Cocktail on Vascular Function and Blood Flow in Cardiovascular Disease Patients

Flow-mediated dilation will be used to measure endothelial function in the brachial artery. This will be done pre- and post-antioxidant intake.

Brachial-to-ankle pulse-wave velocity and carotid-to-femoral pulse-wave velocity will be used to measure arterial stiffness. This will be done pre- and post-antioxidant intake.

Doppler ultrasound will be used to measure blood flow in the femoral and popliteal arteries. This will be done pre- and post-antioxidant intake.

10 mL of blood will be drawn from an antecubital vein pre- and post-antioxidant intake.

Heart rate variability will be measured to determine autonomic function. This will be done pre- and post-antioxidant intake.

Muscle tissue oxygenation will be assessed using near-infrared spectroscopy (NIRS) during a maximal walking protocol pre- and post-antioxidant intake.

Physical walking capacity will be measured using the Gardner treadmill protocol pre- and post-antioxidant intake.

flavanoid/інсульт

Effects of Oral Antioxidant Cocktail in Cardiovascular Disease Patients

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