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gelatinase/інсульт
Посилання зберігається в буфері обміну
15 результати
Gelatinase inhibitors and use thereof
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CROSS-REFERENCE TO RELATED APPLICATIONS
The present application is a national phase entry under 35 U.S.C. .sctn. 371 of International Application No. PCT/EP2016/077632, filed Nov. 15, 2016, published as International Publication No. WO 2017/085034 A1, which claims priority from European Patent
Gelatinase inhibitors and prodrugs
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BACKGROUND OF THE INVENTION
Evidence is accumulating that damage to neurons and apoptotic death of neurons play a role in the pathogenesis of many conditions and disorders, including acute and chronic neurologic disorders. These disorders range from acute stroke, head trauma, and epilepsy to more
Gelatinase inhibitors and prodrugs
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BACKGROUND OF THE INVENTION
Evidence is accumulating that damage to neurons and apoptotic death of neurons play a role in the pathogenesis of many conditions and disorders, including acute and chronic neurologic disorders. These disorders range from acute stroke, head trauma, and epilepsy to more
Gelatinase inhibitors and prodrugs
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BACKGROUND OF THE INVENTION
Evidence is accumulating that damage to neurons and apoptotic death of neurons play a role in the pathogenesis of many conditions and disorders, including acute and chronic neurologic disorders. These disorders range from acute stroke, head trauma, and epilepsy to more
Use of immunosuppressants for MMP mediated diseases
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FIELD OF THE INVENTION
This invention relates to a new use of an immunosuppressant. More specifically, this invention relates to a new use of immunosuppressant as matrix metallproteinases production inhibitor (hereinafter, referred to as MMP-production inhibitor).
BACKGROUND ART
Matrix
Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases
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BACKGROUND OF THE INVENTION
The present invention relates to novel tricyclic sulfonamide compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to
Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases
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BACKGROUND OF THE INVENTION
The present invention relates to novel tricyclic sulfonamide compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to
Biphenyl hydroxy imino butyric acids and their derivatives for treating arthritis
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BACKGROUND OF THE INVENTION
The present invention relates to novel biphenyl butyric acid compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to
Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
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BACKGROUND OF THE INVENTION
The present invention relates to novel heteroaryl butyric acid compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to
Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases
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BACKGROUND OF THE INVENTION
The present invention relates to novel tricyclic heteroaromatic compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to
Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases
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BACKGROUND OF THE INVENTION
The present invention relates to novel fluorinated butyric acid compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to
Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases
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BACKGROUND OF THE INVENTION
The present invention relates to novel benzene butyric acid compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to
Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases
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BACKGROUND OF THE INVENTION
The present invention relates to novel benzene butyric acid compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to
Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
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BACKGROUND OF THE INVENTION
The present invention relates to novel fluorine-substituted biphenyl butyric acid compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically
Flourine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
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BACKGROUND OF THE INVENTION
The present invention relates to novel fluorine-substituted biphenyl butyric acid compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically
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