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FIELD OF THE INVENTION
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to co-administration of an inhibitor of cyclooxygenase-2 and a 5-lipoxygenase inhibitor for treating inflammation and inflammation-related disorders, such as arthritis.
BACKGROUND
This application is a 371 of PCT/FR98/00765, filed Apr. 16, 1998.
The present invention relates to the use of mizolastine, 2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidyl]methyl amino]-4-pyrimidinol or 2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidyl]methyl
FIELD OF THE INVENTION
The present invention relates to novel compounds and medical methods of treatment of inflammation, atherosclerosis and restenosis. More particularly, the present invention concerns the use of novel benzimidazole derivatives.
BACKGROUND OF THE INVENTION
Lipoxygenases are
BACKGROUND OF THE INVENTION
The present invention is directed to the provision of compounds having potent anti-inflammatory and anti-oxidant activity. The invention is further directed to compositions containing the compounds of the present invention for use in pharmaceutical applications. The
BACKGROUND OF THE INVENTION
The present invention is directed to the provision of compounds having potent anti-inflammatory and anti-oxidant activity. The invention is further directed to compositions containing the compounds of the present invention for use in pharmaceutical applications. The
This invention relates to novel substituted indene-, indole-, pyrano-indole- and tetrahydrocarbazole alkanoic acid derivatives possessing lipoxygenase inhibitory, phospholipase A.sub.2 inhibitory and leukotriene antagonist activity, which are useful as anti-inflammatory, antiallergic and
BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioethers, sulfoxides, and disulfides and more particularly relates to the novel compounds of formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy
BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioalkylamides and more particularly relates to the novel compounds of Formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy agents.
It is well
BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioalkylamides and more particularly relates to the novel compounds of Formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy agents.
It is well
BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioether derivatives and more particularly relate to the novel compounds of Formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy agents.
It is well
BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioether derivatives and more particularly relates to the novel compounds of Formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy agents.
It is well
BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioethers and more particularly relates to the novel compounds of formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy agents.
It is well recognized
BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioethers and more particularly relates to the novel compounds of formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy agents.
It is well recognized
BACKGROUND OF THE INVENTION
A. Field of the Invention
The present invention relates to compounds and pharmaceutical compositions which inhibit lipoxygenase and are useful as anti-inflammatory and anti-allergy agents.
It is well recognized that arachidonic acid, an essential unsaturated fatty acid,
BACKGROUND OF THE INVENTION
A. Field of the Invention
The present invention relates to compounds and pharmaceutical compositions which inhibit lipoxygenase and are useful as anti-inflammatory and anti-allergy agents.
It is well recognized that arachidonic acid, an essential unsaturated fatty acid,