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OBJECTIVE
We have previously shown that the transcriptional inhibitor tetra-O-methyl nordihydroguaiaretic acid (M4N) induces growth arrest in tumor cells and exhibits tumoricidal activity when injected intratumorally into tumor cell explants in mice. The experiments reported here were designed to
In line with the (metabolic) rate-of-living theory of aging, previous work from this laboratory showed that the life-prolonging effect of the antioxidant thiazolidine carboxylic acid (TCA) in Drosophila was paralleled by a similar reduction of the oxygen consumption rate of the flies. To assess the
The specific activity of lipoxygenase from several strains of the zygomycete Mortierella varied from 1.02 to 2.02 microMol diene per min per mg protein). The enzyme equally used linoleic or arachidonic acid as a substrate. An increase in lipoxygenase activity was observed after adding corn oil to
A simple and reliable method is described for rapid identification of ascorbyl palmitate, butylated hydroxyanisole, butylated hydroxytoluene, ethoxyquin, gallates (lauryl, octyl, propyl), nordihydroguaiaretic acid, 3,3'-thiodipropionic acid, tocopherol, t-butylhydroquinone, and