5 результати
The number of hepatic peroxisomes, cores, marginal plates, and microperoxisomes in piglets increases from a low level at birth, compared with other species e.g. the rat, to day 28 of life. The number of peroxisomes is correlated to the activity of uricase, but morphometry alone is not sufficient to
OBJECTIVE
To evaluate efficacy and safety of pegloticase, approved by the Food and Drug Administration in September 2010 for treatment of patients with chronic treatment-refractory gout.
METHODS
Literature searches were conducted using PubMed (1948-January 2012), TOXLINE, International
OBJECTIVE
The purpose of this review is to highlight the recent developments in the management of gout.
RESULTS
Guidelines for the diagnosis and management of gout from EULAR, quality of care indicators, and outcome measures for clinical trials have been published. The standards of gout diagnosis
The use of polymers for delivering peptide and protein drugs is described. Soluble-polymer technology attempts to bind a polymer to all sites on therapeutic protein molecules that cause the body to recognize the molecules as foreign. Goals include a stable linkage, water solubility, low
Serum uric acid (UA) is the final product of purine metabolism in humans. The present study is aimed at identifying the potential association between serum UA and early-onset coronary artery disease (EOCAD). The study population consisted of 1093 EOCAD patients aged ≤50 years, and 1117 age- and