Zhongguo Zhongyao Zazhi 2000-Jul
[Studies on chemical constituents in the root of Desmos grandifolius (I)].
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OBJECTIVE
To investigate new compounds with anti-tumor activities from the root of Desmos grandifolius of Annonaceae.
METHODS
The chemical constituents were isolated by silica gel column chromatography, and the structures were elucidated by UV, IR, MS, 1H NMR, 13C NMR, H-H COSY and NOESY analysis.
RESULTS
Six compounds have been isolated from the CHCl3 extract of this plant and identified as lawinal(I), isolawinal(II), desmethoxymatteucinol(III), benzoic acid(IV), beta-sitosterol(V) and sitgmasterol (VI).
CONCLUSIONS
All compounds were found from this plant for the first time. Three dihydroflavonoids isolated from this species are characterized by A-ring substitution and no B-ring substitution.
