Advanced Ultrasound Methods in the Assessment of Carotid Plaque Instability
关键词
抽象
描述
The project will include 3 studies:
Study 1:
Analyse the correlation between SMI assessed neovascularization and degree of stenosis in symptomatic patients with high-grade (>50%) carotid stenosis versus asymptomatic patients with high-grade (>50%) carotid stenosis.
All patients upon inclusion will undergo:
- Clinical, neurological evaluation
- Blood tests
- SMI, CEUS and SWE ultrasound
- Carotid MRI
- PET (subgroup)
- DW-MRI
- Histological assessments after the removal of plaque at carotid endarterectomy (CEA).
Study 2:
SMI and vascular events. Asymptomatic patient's follow-up at 12 months:
- Clinical neurological evaluation
- Blood test
- SMI, CEUS, SWE ultrasound
- Carotid MRI
- PET (subgroup)
Study 3:
This study will use the same patient pool described in study 1 undergoing the previously described procedural examinations upon inclusion and at one year follow up. Quantification of stiffness/elasticity in the artery wall will be performed and compared to plaque echogenicity measured as GSM . These results will be correlated to histology of the carotid plaque after trombendarterectomy, risk markers in blood (lipids, HbA1c, CRP, leukocytes), other cardiovascular risk markers (hypertension, diabetes, nicotine) and cerebrovascular symptoms.
日期
| 最后验证: | 09/30/2018 |
| 首次提交: | 09/10/2018 |
| 提交的预估入学人数: | 09/13/2018 |
| 首次发布: | 09/16/2018 |
| 上次提交的更新: | 10/09/2018 |
| 最近更新发布: | 10/14/2018 |
| 实际学习开始日期: | 08/31/2016 |
| 预计主要完成日期: | 08/31/2018 |
| 预计完成日期: | 12/31/2019 |
状况或疾病
相
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 取样方式 | Non-Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Atherosclerotic carotid stenosis >50% with or without cerebrovascular symptoms. Exclusion Criteria: - Malignancies - Inflammatory disease |
结果
主要结果指标
1. Raised neovascularization and increased stiffness of the carotid artery wall are correlated to cerebrovascular symptoms and raised level of some plasma markers. [one year]
次要成果指标
1. Increased neovascularization in the carotid artery wall assessed by SMI ultrasound is correlated to cerebrovascular symptoms, ischemic lesions on cerebral MR, increased level of some plasma markers and increased vascularization on carotid plaques [At inclusion]
2. Increased neovascularization in the carotid artery wall assessed by SMI ultrasound is correlated to cerebrovascular symptoms, ischemic lesions on cerebral MR and increased level of some plasma markers at one year follow-up [1 year]
3. Increased stiffness in the carotid artery wall assessed by ultrasound (GSM) is correlated to cerebrovascular symptoms and increased level of some plasma markers at one year follow-up [1]
