Autonomic Activity During Nap Under Hypoxia
关键词
抽象
日期
| 最后验证: | 10/31/2019 |
| 首次提交: | 10/24/2019 |
| 提交的预估入学人数: | 10/29/2019 |
| 首次发布: | 10/30/2019 |
| 上次提交的更新: | 11/04/2019 |
| 最近更新发布: | 11/05/2019 |
| 实际学习开始日期: | 10/29/2019 |
| 预计主要完成日期: | 10/29/2020 |
| 预计完成日期: | 10/29/2021 |
状况或疾病
干预/治疗
Other: Normoxia
Other: Hypoxia 1
Other: Hypoxia 2
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Placebo Comparator: Normoxia 20.9% oxygen | Other: Normoxia Nap in hypoxia chamber at 20.9% oxygen (36 m asl) |
| Active Comparator: Hypoxia 1 15.0% oxygen | Other: Hypoxia 1 Nap in hypoxia chamber at 15.0% oxygen (simulates 2660 m asl) |
| Active Comparator: Hypoxia 2 12.8% oxygen | Other: Hypoxia 2 Nap in hypoxia chamber at 12.8% oxygen (simulates 4000 m asl) |
资格标准
| 有资格学习的年龄 | 25 Years 至 25 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Men and women - Age 25-45 years - BMI 20 - 28 kg/m^2 Exclusion Criteria: - Severe, manifest illnesses in need of treatment - Postoperative phases - Acute and chronic infections - Sleep disorders such as sleep apnea, insomnia or somnolence - Altitude exposure (> 2500 m asl) within 6 months before enrollment - Regular migraines - Smoking - Athletes - Significant weight change within 1 month before enrollment - Inability to understand significance and scope of the study - Drug or alcohol abuse |
结果
主要结果指标
1. Heart rate variability [During 90 minutes nap under normoxic (20.9%) vs. 12.8% hypoxic condition]
次要成果指标
1. Heart rate variability [During 90 minutes nap under normoxic (20.9%) vs. 15.0% hypoxic condition]
2. Sleep Efficiency (SE) [During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
3. Wake After Sleep Onset (WASO) [During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
4. Sleep Onset Latency (SOL) [During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
5. Low Frequency / High Frequency Band [During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
6. Standard Deviation 1 / Standard Deviation 2 [During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
7. RR intervals longer than 50 ms [During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
8. Core Body Temperature [During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
9. Skin Temperature [During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
10. Digit Span Task [After 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
11. Psychomotor Vigilance Task Subscale 1 [After 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
12. Psychomotor Vigilance Task Subscale 2 [After 90 min nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
13. Color Stroope Task Subscale 1 [After 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
14. Color Stroope Task Subscale 2 [After 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
15. Color Stroope Task Subscale 3 [After 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
16. Color Stroope Task Subscale 4 [After 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
17. Color Stroope Task Subscale 5 [After 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%)]
