Bioavailability of Xanthones From Mangosteen
关键词
抽象
描述
Garcinia mangostana L. (mangosteen) is a tropical tree native to Southeast Asia. The pericarp of mangosteen fruit is used in traditional medicine to treat inflammation, infections, wounds, and diarrhea. The proposed health-promoting effects have been attributed to a family of polyphenols referred to as xanthones. Since its introduction into the United States, juices and products containing mangosteen fruit have become a top-selling botanical dietary supplement. This commercial success largely has been the result of aggressive marketing of health claims based on in vitro observations and anecdotal reports.
The purpose of this study was to determine the bioavailability of xanthones from mangosteen juice in adult human subjects. After an overnight fast of at least 10h, male and female subjects were admitted to the Ohio State University Clinical Research Center. Volunteers ingested 2 ounces of 100% mangosteen juice as part of a western-style breakfast. Pericarp particles accounted for 1% of the mass and 99% of total xanthone content in the juice. This dose provided 130 ± 2 mg total xanthones. Blood was collected prior to breakfast and 1,2,3,4,6,8 and 24h. Subjects were fed a mangosteen-free lunch and released from the unit after the 8h collection, refraining from mangosteen containing products until final collection of blood at 24h. Urine was collected for the 24 test period.
日期
最后验证: | 07/31/2011 |
首次提交: | 08/25/2011 |
提交的预估入学人数: | 08/25/2011 |
首次发布: | 08/28/2011 |
上次提交的更新: | 08/30/2011 |
最近更新发布: | 09/01/2011 |
实际学习开始日期: | 10/31/2010 |
预计主要完成日期: | 10/31/2010 |
预计完成日期: | 01/31/2011 |
状况或疾病
相
手臂组
臂 | 干预/治疗 |
---|---|
Females ingesting mangosteen juice | |
Males ingesting mangosteen juice |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
取样方式 | Non-Probability Sample |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - 5 female - 5 male - body mass index = 30 - normal renal function - non-smoking Exclusion Criteria: - smokers - acute or chronic diseases - history of gastrointestinal diseases - >/= 10% weight loss - dietary or herbal supplement within 6 months of study - pregnancy |
结果
主要结果指标
1. Xanthones in urine [0-24 hours]
次要成果指标
1. Xanthones in sera [0-24 hours]