Blackberry Intake and Biomarkers of Cancer Risk
关键词
抽象
日期
| 最后验证: | 06/30/2011 |
| 首次提交: | 01/23/2011 |
| 提交的预估入学人数: | 02/08/2011 |
| 首次发布: | 02/09/2011 |
| 上次提交的更新: | 07/14/2011 |
| 最近更新发布: | 07/17/2011 |
| 实际学习开始日期: | 12/31/2010 |
| 预计主要完成日期: | 03/31/2011 |
| 预计完成日期: | 03/31/2011 |
状况或疾病
干预/治疗
Other: Blackberries
Other: Gelatin
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Placebo Comparator: Gelatin | Other: Gelatin 300 g gelatin per day for 5 days |
| Experimental: Blackberries | Other: Blackberries 300 g blackberries daily for 5 days |
资格标准
| 有资格学习的年龄 | 40 Years 至 40 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Non-smoking men and women - Aged 40-75 - BMI 19-38 kg/m2 Exclusion Criteria: - Younger then 40 ears old or older than 75 years old - BMI less than 19 or greater than 38 - Use of blood-thinning medications such as warfarin, dicumarol, or anisinidione - Presence of kidney disease, liver disease, gout, certain cancers, untreated thyroid, gastrointestinal, other metabolic diseases or malabsorption syndromes - Type 2 diabetes requiring the use of oral antidiabetic agents or insulin - Fasting triglycerides greater than 300 mg/dL - Fasting glucose greater than 126 mg/dL - History of eating disorders or other dietary patterns which are not consistent with the dietary intervention (e.g. vegetarians, very low fat diets, high protein diets) - Use of prescription of over-the-counter antiobesity medications or supplements during and for at least 6 months prior to the start of the study or a history of a surgical intervention for obesity - Active cardiovascular disease - Use of any tobacco products in the past 6 months - Use of oral or IV antibiotics during the month preceding the study or during the study - Unwillingness to abstain from vitamin, mineral, and herbal supplements for two weeks prior to the start of the study - Known (self-reported) allergy or adverse reaction to blackberries or gelatin - Unable or unwilling to give informed consent or communicate with study staff - Self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in Alcoholics Anonymous is not an exclusion) - Other medical, psychiatric, or behavioral factors that in the judgment of the Principal Investigator may interfere with study participation or the ability to follow the intervention protocol |
结果
主要结果指标
1. Change from baseline in 8-oxo-dG levels after 5 days [Day 5]
