Brain fMRT In Takotsubo Cardiomyopathy
关键词
抽象
日期
最后验证: | 02/28/2019 |
首次提交: | 09/10/2014 |
提交的预估入学人数: | 09/11/2014 |
首次发布: | 09/14/2014 |
上次提交的更新: | 03/04/2019 |
最近更新发布: | 03/06/2019 |
实际学习开始日期: | 09/30/2014 |
预计主要完成日期: | 11/30/2018 |
预计完成日期: | 02/28/2019 |
状况或疾病
相
手臂组
臂 | 干预/治疗 |
---|---|
TTC postmenopausal women with acute Takotsubo cardiomyopathy (TTC), diagnosis by coronary angiography within 24 hours of symptom onset | |
NSTEMI / STEMI postmenopausal women with acute ST elevation myocardial infarction (NSTEMI / STEMI), diagnosis by coronary angiography within 24 hours of symptom onset | |
healthy subjects healthy postmenopausal women without coronary artery disease |
资格标准
有资格学习的性别 | Female |
取样方式 | Probability Sample |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Postmenopausal females aged below 90 years - Informed written consent - TTC or NSTEMI / STEMI undergoing coronary angiography within 24 hours of symptom onset Exclusion Criteria: - Delayed coronary angiography (> 24 hours after symptom onset) - Inability to perform rsfMRT within the first 72 hours after coronary angiography - Inability to communicate in German language - Contraindications for a MRT examination (including pacemaker, implantable cardioverter-defibrillator, mechanical heart valves, claustrophobia, severe adipositas) - Drug addiction, under guardianship - Inability to stick to the follow up examination |
结果
主要结果指标
1. Changes in brain functional MRT (resting state, paradigma) in postmenopausal females suffering from TTC as compared to NSTEMI / STEMI postmenopausal female patients [Within the first 72h after diagnosis and after 4-8 weeks]