Brazil Nuts Effects on Selenium Status and Cognitive Performance
关键词
抽象
描述
We enrolled older patients with MCI who attended the Memory and Aging Unit of the Geriatrics Division, University of São Paulo Medical School (Brazil). All participants fulfilled the criteria proposed by the International Working Group on Mild Cognitive Impairment (Winblad et al., 2004), which include the following: (1) the person is neither normal nor demented; (2) there is evidence of cognitive deterioration shown by subjective report in conjunction with objective cognitive deficits; and (3) activities of daily living are preserved and complex instrumental functions are either intact or minimally impaired. The diagnosis of MCI was based on a comprehensive neuropsychological assessment which included the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery (Welsh et al., 1994; Bertolucci et al., 2001). Participants were recruited from May 2011 to August 2012. Eligible subjects were aged 60 years or older, fluent in Portuguese, and free of any other significant neurologic or psychiatric diseases. None of them presented major depression or psychosis, had a regular intake of Brazil nuts, used supplements with selenium, or had intolerance to oleaginous food. An informed consent was obtained before the interview from all participants. The research protocol was approved by the Research Ethics Comittee of the Faculdade de Ciências Farmacêuticas da Universidade de São Paulo.
日期
最后验证: | 03/31/2014 |
首次提交: | 04/20/2014 |
提交的预估入学人数: | 04/21/2014 |
首次发布: | 04/22/2014 |
上次提交的更新: | 04/21/2014 |
最近更新发布: | 04/22/2014 |
实际学习开始日期: | 04/30/2011 |
预计主要完成日期: | 07/31/2012 |
预计完成日期: | 07/31/2012 |
状况或疾病
干预/治疗
Dietary Supplement: Treatment Group
Dietary Supplement: Treatment Group
相
手臂组
臂 | 干预/治疗 |
---|---|
No Intervention: Control Group This group did not receive any intervention. | |
Experimental: Treatment Group This group took one Brazil nut daily during 6 months. | Dietary Supplement: Treatment Group Participants of the treatment group were instructed to take one Brazil nut daily during 6 months. Brazil nuts were supplied in 2-month allowances at no cost together with written nutritional information and a calendar to monitor the compliance. Compliance was monitored in intervals of 2 months by checking the calendar and counting returned nuts. Compliance was considered to be adequate if ≥85% of Brazil nuts were consumed. All subjects were instructed to maintain their normal diet and to avoid additional Brazil nuts during the study. |
资格标准
有资格学习的年龄 | 60 Years 至 60 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - aged 60 years or older, - fluent in Portuguese, - free of any other significant neurologic or psychiatric diseases Exclusion Criteria: |
结果
主要结果指标
1. Selenium level in plasma and erythrocyte [6 months]
次要成果指标
1. cognitive performance [6 months]
其他成果措施
1. Oxidative stress parameters [6 months]