Cannabis Effects on Brain Morphology in Aging
关键词
抽象
日期
| 最后验证: | 03/31/2019 |
| 首次提交: | 06/02/2013 |
| 提交的预估入学人数: | 06/05/2013 |
| 首次发布: | 06/10/2013 |
| 上次提交的更新: | 04/17/2019 |
| 最近更新发布: | 04/21/2019 |
| 实际学习开始日期: | 12/31/2012 |
| 预计主要完成日期: | 11/30/2018 |
| 预计完成日期: | 11/30/2019 |
状况或疾病
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Cannabis users ⋄Heavy Marijuana Users : 60-80 years old; Marijuana use initiated in adolescence with marijuana use of no more than 1-2 x/month after 30 years of age; Used marijuana more than 20 times/month for at least 1 year during this period. Cigarette smoking (tobacco) and alcohol will be allowed in both groups, which will be matched on number of smokers and nicotine dependence, measured according to the Fagerstrőm Test for Nicotine Dependence. Light alcohol use will also be allowed in and matched across both groups (< 14 drinks/week for men; < 7 drinks/week for women; may not meet DSM-IV criteria for alcohol dependence). | |
| Clean or Non-Users ⋄No marijuana use, may smoke cigarettes, fewer than 7 drinks/week (women) or 14 drinks/week (men). 60-80 years old. |
资格标准
| 有资格学习的年龄 | 60 Years 至 60 Years |
| 有资格学习的性别 | All |
| 取样方式 | Non-Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria - Subjects will be 60 heavy users or non-users between 60-80 years of age - Participants who used marijuana during adolescence. Current marijuana usage not allowed and subjects must complete urine screening at the time of inclusion. Exclusion Criteria - Major psychiatric disorders, such bipolar disorder or schizophrenia as revealed by the Structured Clinical Interview for DSM-IV Disorders (100) and exclude for confounding psychiatric conditions - Evidence of untreated depression as determined by a HAM-D Score of >12 (17-item version) or untreated anxiety by a score of > 8 on the Hamilton Anxiety Scale - Evidence of neurologic or other physical illness that could produce cognitive deterioration. - Volunteers with a history of TIAs, carotid bruits, or lacunae on MRI scan will be excluded - History of myocardial infarction within the previous year or unstable cardiac disease - Uncontrolled hypertension (systolic BP > 170 or diastolic BP > 100) - History of significant liver disease - Clinically significant pulmonary disease, diabetes, or cancer - Because medications can affect cognitive functioning, subjects needing medicines that could influence psychometric test results will be excluded. These include: centrally active beta-blockers, narcotics, clonidine, anti-Parkinsonian medications, systemic corticosteroids, benzodiazepines, medications with significant cholinergic or anticholinergic effects, anticonvulsants, or warfarin, and any affecting the serotonin system, which may affect neuropsychological test results. - Current diagnosis or history of alcoholism or dependence on any illicit drugs other than marijuana. - Use of any investigational drugs within the previous month or longer, depending on drug half-life. - Contraindication for MRI scan (e.g. metal in body, claustrophobia). |
结果
主要结果指标
1. Magnetic resonance imaging of hippocampal size [Participants will complete an MRI scan which will take approximately 1 hour]
2. Diffusion tensor imaging (DTI) to investigate white matter structure [Participants will complete an MRI scan with DTI sequence which will take approximately 1 hour]
3. Cognitive performance in a range of neuropsychological tests [Neuropsychological testing will take approximately 3 hours]
