Cerebral Infarction and White Substance in Angiopathy Cerebral Amyloid
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Groupe Hospitalier Paris Saint Joseph
临床试验: NCT03262246
BioSeek: NCT03262246
关键词
抽象
The cerebral amyloïd angiopathy ( AAC) is a disease characterized by deposits of beta-amyloid peptids in the walls of the arteries of young and average calibre of the brain and the leptomeninx. The incidence of the AAC increases strongly with the age and represents a major cause of spontaneous brain haemorrhage to people over 60. The main demonstration is the lobar brain haemorrhage, the other ones are bleedings under arachnoid cortical and microbleedings leading to cognitive decline.
Anatomical studies reported the presence of cortical infarcts in patients having amyloïd deposits suggesting an association between asymptomatic cortical cerebral infarcts and AAC.
However prevalence and meaning of these infarcts in patients having an AAC remain badly known because of studies on low number of patients and the rarity of radiological analyses of these infarcts .A better knowledge of these asymptomatic cortical infarcts would allow to dread better cognitive disorders(confusions) presented by these patients, and to develop preventive strategies.
Besides, the risk factors of severity of the AAC are little studied.
日期
| 最后验证: | 07/31/2018 |
| 首次提交: | 08/23/2017 |
| 提交的预估入学人数: | 08/23/2017 |
| 首次发布: | 08/24/2017 |
| 上次提交的更新: | 01/31/2019 |
| 最近更新发布: | 02/03/2019 |
| 实际学习开始日期: | 06/01/2016 |
| 预计主要完成日期: | 12/30/2016 |
| 预计完成日期: | 12/30/2018 |
状况或疾病
Amyloid Angiopathy
干预/治疗
Other: medical report consultation
相
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资格标准
| 有资格学习的年龄 | 55 Years 至 55 Years |
| 有资格学习的性别 | All |
| 取样方式 | Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - age>55 - hospitalized in CAEN hospital and Paris St Joseph Hospital between 1st january 2011 and 31 december 2015 for cerebral haemorrhage with MRI images diagnosing cerebral amyloid angiopathy. Exclusion Criteria: - Insufficient MRI images quality without FLAI sequence, T2 GRE - disease with same radiologic and clinical signs that cerebral amyloid angiopathy. |
结果
主要结果指标
1. number of patient with cerebral infarction and associated factors in a cohort of cerebral amyloid angiopathy patients [1day]
