Comparison of Drugs on Headache Treatment After ECT Treatment
关键词
抽象
描述
Electroconvulsive treatment (ECT) is used as an alternative application instead of drug therapy for psychiatric symptoms. ECT application is repeated 8-12 times according to the treatment of the patient. This treatment is done in 2 or 3 days intervals. The most adverse effects of ECT are headache, memory disorders, myalgia, nausea and vomiting, cardiovascular problems. The most common seen adverse effect is headache with approximately 60% incidence. The main drugs used for the treatment of headache related to ECT are NSAIs and paracetamol. The aim of the current study is to compare the effect of paracetamol and dexketoprofen trometamol on headache treatment after ECT.
日期
| 最后验证: | 01/31/2019 |
| 首次提交: | 01/14/2019 |
| 提交的预估入学人数: | 02/01/2019 |
| 首次发布: | 02/04/2019 |
| 上次提交的更新: | 02/01/2019 |
| 最近更新发布: | 02/04/2019 |
| 实际学习开始日期: | 11/19/2018 |
| 预计主要完成日期: | 04/30/2019 |
| 预计完成日期: | 05/31/2019 |
状况或疾病
干预/治疗
Drug: Paracetamol
Drug: Deksketoprofen trometamol
Drug: Placebo
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Active Comparator: Paracetamol Parol group: intravenous infusion in 30 min Generic name: Parol Dosage form: intravenous Dosage: 1 gr Frequency: preop one dose only Duration: For one week | Drug: Paracetamol The investigators apply paracetamol during a week in preoperative room 45 min before ECT |
| Active Comparator: Deksketoprofen trometamol Sertofen group: intravenous infusion in 30 min Generic name: Sertofen Dosage form: intravenous Dosage: 50 mg Frequency: preop one dose only Duration: For one week | Drug: Deksketoprofen trometamol The investigators apply paracetamol during a week in preoperative room 45 min before ECT |
| Placebo Comparator: Placebo Placebo group: intravenous infusion in 30 min Generic name: Serum physiologic Dosage form: intravenous Dosage: 100 ml Frequency: preop one dose only Duration: For one week | Drug: Placebo The investigators apply placebo during a week in preoperative room 45 min before ECT |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - All patients who were admitted for ECT and gave informed written consent were included in the study. Exclusion Criteria: - Exclusion criteria included patients who gave a history of allergy to acetaminophen, lacked capacity to give informed consent and developed complications such as delirium following ECT. |
结果
主要结果指标
1. Headache (Visual Analogue Scale 0-10) [Postoperative 2. hour, 4. hour, 6. hour (up to six hours after intervention)]
次要成果指标
1. Additive analgesic-antiemetic consumption [Postoperative 2. hour, 4. hour, 6. hour (up to six hours after intervention)]
2. Adverse effects (Nausea-Vomiting, bradycardia, hypotension) [Postoperative 2. hour, 4. hour, 6. hour (up to six hours after intervention)]
